Evidence map›Paper›PMID 38415554›Full record

SynthesisAsian Pacific journal of cancer prevention : APJCP2024

Lack of Association between TP73 G4C14-A4T14 Polymorphism and Cervical Cancer Risk in Overall and Asian Women: A Meta-Analysis.

Maryam Motamedinasab, Mojgan Karimi-Zarchi, Zahra Marzbanrad, Seyedeh Roghayeh Mirmohammadi, Mohammad Vakili-Ojarood, Sepideh Azizi, Maedeh Barahman, Maryam Yeganegy, Maryam Aghasipour, Sahel Khajehnoori and 2 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Maryam MotamedinasabDepartment of Obstetrics and Gynecology, Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Mojgan Karimi-ZarchiDepartment of Gynecologic Oncology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Zahra MarzbanradDepartment of Obstetrics and Gynecology, Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Seyedeh Roghayeh MirmohammadiDepartment of Obstetrics and Gynecology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Mohammad Vakili-OjaroodDepartment of Surgery, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Sepideh AziziShahid Akbarabadi Clinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran.
Maedeh BarahmanDepartment of Radiation Oncology, Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Maryam YeganegyDepartment of Obstetrics and Gynecology, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Maryam AghasipourDepartment of Cancer Biology, College of Medicine, University of Cincinnati, Ohio, USA.
Sahel KhajehnooriHematology and Oncology Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Kazem AghiliDepartment of Radiology, Shahid Rahnemoun Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein NeamatzadehMother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Iran University of Medical Sciences · IRShahid Sadoughi University of Medical Sciences and Health Services · IRFiroozgar General Hospital · IRAlborz University of Medical SciencesArdabil University of Medical Sciences · IRIranshahr University · IRUniversity of Cincinnati Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowing studies revealed the association between polymorphisms in Tumor Protein TP73 (TP73) and susceptibility to cancer, especially with gynecological cancers. but, the results remained inconsistent. This meta-analysis was carried out to examine the relationship of the TP73 G4C14-to-A4T14 polymorphism (hereafter, G4C14-to-A4T14) with susceptibility to cervical cancer globally and by ethnicity.

methodsEligible studies were collected by retrieving PubMed, Scopus, Web of Science, Embase, Wan Fang, and CNKI published before 25 October, 2023. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of such association.

resultsA total of 10 case-control studies with 1804 cervical cancer cases and 2433 healthy controls were included to this study. The pooled results showed that TP73 G4C14-to-A4T14 polymorphism was not associated with cervical cancer risk in overall. in terms of stratified analyses by ethnicity, this polymorphism was not associated with risk of cervical cancer among East-Asian women. however,  there was a significant association based source of control among hospital-based studies.

conclusionsInconsistent with previous meta-analyses, our pooled results revealed that TP73 G4C14-to-A4T14 polymorphism might not be a risk factor for development of cervical cancer globally and among East-Asian women. Moreover, further studies examining the effect of gene-gene and gene-environment interactions may eventually provide a better knowledge.

Indexed as

Uterine Cervical NeoplasmsCase-Control StudiesDNA-Binding ProteinsFemaleGenetic Predisposition to DiseaseHumansNuclear ProteinsPolymorphism, Single NucleotideRisk FactorsTumor Protein p73Tumor Suppressor ProteinsDNA-Binding ProteinsNuclear ProteinsTumor Protein p73Tumor Suppressor ProteinsPolymorphismTumor Protein TP73Uterine Cervical Neoplasms

Identifiers

PMID38415554
PMCPMC11077128
OpenAlexW4392246001

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.