Evidence map›Paper›PMID 38415672›Full record

ArticleConnective tissue research2024

Assessment of articular cartilage degradation in response to an impact injury using µMRI.

Amanveer Singh, Hannah Mantebea, Farid Badar, Syeda Batool, Gabrielle Abdelmessih, Talia Sebastian, Michael Newton, Kevin Baker, Sarah Salem, Yang Xia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Connective tissue research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Amanveer SinghDepartment of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, USA.
Hannah MantebeaDepartment of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, USA.
Farid BadarDepartment of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, USA.
Syeda BatoolDepartment of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, USA.
Gabrielle AbdelmessihDepartment of Chemistry, Oakland University, Rochester, MI, USA.
Talia SebastianDepartment of Chemistry, Oakland University, Rochester, MI, USA.
Michael NewtonOrthopedic Research Laboratories, Beaumont Health, Royal Oak, MI, USA.
Kevin BakerOrthopedic Research Laboratories, Beaumont Health, Royal Oak, MI, USA.
Sarah SalemDepartment of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, USA.
Yang XiaDepartment of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, USA.ORCID 0000-0003-4653-1862
Oakland University · USBeaumont Health · USUniversity of Michigan · US

Funding

ACL Deficiency Modifies Topographical Degradation in Posttraumatic OsteoarthritisR01AR069047 · NIAMS · OAKLAND UNIVERSITY · PI XIA, YANG · 2016 to 2022
$2.2M
NIAMS NIH HHS R01 AR069047
6 · The paper itself

Abstract

purposeDegradation of articular cartilage (AC) due to injury to the knee joint may initiate post-traumatic osteoarthritis (PTOA). Failure to diagnose the onset of the disease at an early stage makes the cure ineffective for PTOA. This study investigated the consequences of a mechanical injury to the knee in a rabbit model using microscopic magnetic resonance imaging (µMRI) at high resolution. MATERIALS AND

methodsA mechanical injury was induced to the knee joints of 12 rabbits. Cartilage blocks were extracted from the non-impacted and impacted knee joints after 2 and 14 weeks post-impact. The specimens were studied using µMRI T2 relaxation and inductively coupled plasma analysis to determine the early degradation of the articular cartilage.

resultsThe data established a connection between T2 relaxation time and the early progression of knee PTOA after an impact injury. T2 values were found to be higher in the impacted cartilage at both 2 and 14 weeks, in particular, T2-55° values in the impacted samples displayed a significant rise of 6.93% after 2 weeks and 20.02% after 14 weeks. Lower glycosaminoglycan measurement and higher water content in the impacted cartilage confirmed the µMRI results.

conclusionsThis µMRI T2 study was able to detect cartilage damage in the impacted knees. In addition, greater degradation in the affected knees at 14 weeks than at 2 weeks indicated the progressive nature of cartilage deterioration over time. The µMRI results were in accord with the biochemical analysis, indicating the detection of early structural damage in the cartilage.

Indexed as

Cartilage, ArticularOsteoarthritisAnimalsDisease Models, AnimalKnee JointMagnetic Resonance ImagingRabbitsarticular cartilageimpact injurypost-traumatic osteoarthritisT2 relaxationμMRI

Identifiers

PMID38415672
PMCPMC10994738
OpenAlexW4392240665

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.