Evidence mapPaperPMID 38416844Full record

ArticleScience translational medicine2024

Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition.

Jonathan P Sturgeon, Joice Tome, Cherlynn Dumbura, Florence D Majo, Deophine Ngosa, Kuda Mutasa, Kanekwa Zyambo, Ellen Besa, Kanta Chandwe, Chanda Kapoma and 10 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. High-dose vitamin DNature communications · 2025
    Trial
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 3 countries.

Jonathan P SturgeonZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.ORCID 0000-0003-1318-1739
Joice TomeZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Cherlynn DumburaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.ORCID 0000-0002-1704-0274
Florence D MajoZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.ORCID 0009-0006-1282-0462
Deophine NgosaTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.ORCID 0000-0002-9019-9046
Kuda MutasaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.ORCID 0000-0003-4158-6282
Kanekwa ZyamboTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.ORCID 0000-0001-5686-5319
Ellen BesaTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.ORCID 0000-0001-5606-9435
Kanta ChandweTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.ORCID 0000-0003-1403-8432
Chanda KapomaTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.ORCID 0000-0001-6404-1686
Benjamin MwapenyaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.ORCID 0009-0003-6174-3879
Kusum J NathooFaculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Claire D BourkeZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.ORCID 0000-0002-7244-0895
Robert NtoziniZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.ORCID 0000-0002-8543-2835
Bernard ChasekwaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Melanie SmukBlizard Institute, Queen Mary University of London, London E1 2AT, UK.ORCID 0000-0002-1594-1458
Mutsa Bwakura-DangarembiziZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.ORCID 0000-0001-7751-6177
Beatrice AmadiTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.ORCID 0000-0001-6363-2943
Paul KellyBlizard Institute, Queen Mary University of London, London E1 2AT, UK.ORCID 0000-0003-0844-6448
Andrew J PrendergastZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.ORCID 0000-0001-7904-7992
Zvitambo Institute for Maternal and Child Health Research · ZWUniversity of Zambia · ZMQueen Mary University of London · GBUniversity of Zimbabwe · ZW

Funding

Medical Research Council MR/K012711/1Wellcome Trust 107634Wellcome Trust 108065Wellcome Trust 206225Wellcome Trust 206225/Z/17/ZWellcome Trust 220566
6 · The paper itself

Abstract

Severe acute malnutrition (SAM) is the most high-risk form of undernutrition, particularly when children require hospitalization for complications. Complicated SAM is a multisystem disease with high inpatient and postdischarge mortality, especially in children with comorbidities such as HIV; however, the underlying pathogenesis of complicated SAM is poorly understood. Targeted multiplex biomarker analysis in children hospitalized with SAM (

Indexed as

HIV InfectionsMalnutritionSevere Acute MalnutritionAftercareChildHumansInfantInflammationIntercellular Signaling Peptides and ProteinsPatient DischargePatient ReadmissionVascular Endothelial Growth Factor AIntercellular Signaling Peptides and ProteinsVascular Endothelial Growth Factor A

Identifiers

PMID38416844
PMCPMC7615785
OpenAlexW4392230365

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.