Evidence map›Paper›PMID 38419059›Full record

ArticleLipids in health and disease2024

Appraising associations between signature lipidomic biomarkers and digestive system cancer risk: novel evidences from a prospective cohort study of UK Biobank and Mendelian randomization analyses.

Yuanlin Sun, Donghui Cao, Yang Zhang, Yanhua Wu, Zhifang Jia, Yingnan Cui, Dongming Li, Xueyuan Cao, Jing Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yuanlin SunDepartment of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Donghui CaoDepartment of Clinical Epidemiology, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Yang ZhangDepartment of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Yanhua WuDepartment of Clinical Epidemiology, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Zhifang JiaDepartment of Clinical Epidemiology, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Yingnan CuiDepartment of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Dongming LiDepartment of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Xueyuan CaoDepartment of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China. jd3d2ub@jlu.edu.cn.
Jing JiangDepartment of Clinical Epidemiology, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China. jiangjing19702000@jlu.edu.cn.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

Education Department of Jilin Province JJKH20221074KJJilin Province Department of Finance JLSWSRCZX2020-010Jilin Provincial Scientific and Technological Development Program 20210101333JCJilin Provincial Scientific and Technological Development Program 20210101436JCJilin Provincial Scientific and Technological Development Program YDZJ202201ZYTS133National Natural Science Foundation of China 81874279National Natural Science Foundation of China 82002932
6 · The paper itself

Abstract

backgroundThe roles of serum lipids on digestive system cancer (DSC) risk were still inconclusive. In this study, we systematically assessed indicative effects of signature lipidomic biomarkers (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG)) on DSC (oesophagus, stomach, colorectal, liver, gallbladder, and pancreas cancers) risk.

methodsHDL-C, LDL-C, and TG concentration measurements were respectively analyzed with enzyme immunoinhibition, enzymatic selective protection, and GPO-POD methods in AU5800 supplied from Beckman Coulter. The diagnoses of DSCs were coded using International Classification of Diseases, Tenth Revision (ICD-10) codes updated until October 2022 in the UK Biobank (UKB). In this study, we assessed phenotypic association patterns between signature lipidomic biomarkers and DSC risk using restricted cubic splines (RCSs) in multivariable-adjusted Cox proportional hazards regression models. Moreover, linear and nonlinear causal association patterns of signature lipidomic biomarkers with DSC risk were determined by linear and nonlinear Mendelian randomization (MR) analyses.

resultsA median follow-up time of 11.8 years was recorded for 319,568 participants including 6916 DSC cases. A suggestive independent nonlinear phenotypic association was observed between LDL-C concentration and stomach cancer risk (P

conclusionsOur findings confirmed indicative roles of signature lipidomic biomarkers on DSC risk, notably detecting suggestive evidences for a protective effect of high LDL-C concentration on stomach cancer risk, and a detrimental effect of high TG concentration on gallbladder cancer risk among given participants.

Indexed as

Gallbladder NeoplasmsStomach NeoplasmsBiological Specimen BanksBiomarkersCholesterol, HDLCholesterol, LDLFemaleHumansLipidomicsMaleMendelian Randomization AnalysisProspective StudiesRisk FactorsTriglyceridesUK BiobankBiomarkersCholesterol, HDLCholesterol, LDLTriglyceridesCausal associationsDigestive system cancer riskLinear and nonlinear Mendelian randomization analysisPhenotypic associationsPolygenic risk scoreSignature lipidomic biomarkers

Identifiers

PMID38419059
PMCPMC10900802
OpenAlexW4392238963

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.