ArticleJournal of cellular physiology2024
ATF4-dependent increase in mitochondrial-endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle.
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Article in Journal of cellular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
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Who cites it
25 citing papers in PubMed, 26 citations in OpenAlex.
- Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review).Molecular medicine reports · 2026Review
- Cardiac extracellular vesicle proteomics identifies mitochondrial and contractile dysfunction in carbon monoxide poisoning and their reversal by hyperbaric oxygen therapy.Molecular medicine (Cambridge, Mass.) · 2026Article
- 3D EM uncovers mitochondrial network remodeling in residual triple negative breast cancer after conventional chemotherapy treatments.iScience · 2026Article
- Transplantation of AQP1-overexpressing mitochondria attenuates periodontitis-associated bone loss by regulating mitochondria-ER contacts of macrophages.Journal of nanobiotechnology · 2026Article
- Exercise-induced modulation of the unfolded protein response: a therapeutic avenue for muscle wasting disorders.Journal of physiology and biochemistry · 2026Review
- Stress-Encoded Mitochondrial Plasticity: ATF4 Control of Mega-Mitochondria and Nanotunnel Communication.bioRxiv : the preprint server for biology · 2026Article
- MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.Nature structural & molecular biology · 2026Article
- ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle.bioRxiv : the preprint server for biology · 2026Article
- Role of Activating Transcription Factor 4 in Metabolic, Neurologic, and Ocular Diseases.Cells · 2026Review
- Microscopy in mitochondrial research - a comprehensive review.Journal of cell science · 2026Review
- Dynamic imbalance of mitochondria-associated ER membranes in cardiovascular disease: mechanisms, context dependence and therapeutic potential.Frontiers in cell and developmental biology · 2026Review
- Roles of DRP1 and the fission protein interactome as regulators of cellular stability and sarcopenia in skeletal muscle aging.Aging advances · 2025Article
- The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Narrative review of mitochondrial dysfunction in aging-related salt-sensitive hypertension: outcomes, mechanisms, and therapeutic implications.Aging advances · 2025Article
- Small-molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in acute myeloid leukemia.Science advances · 2025Article
- Mitochondrial‑endoplasmic reticulum crosstalk: Molecular mechanisms and implications for cardiovascular disease (Review).Molecular medicine reports · 2025Review
- Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise.Aging cell · 2025Article
- Intracellular Membrane Contact Sites in Skeletal Muscle Cells.Membranes · 2025Review
- Protective effects of Salubrinal against HFrontiers in pharmacology · 2025Article
- Mitochondria-ER contact site components regulate the formation and localization of specialized high-capacity mitochondria in themicroPublication biology · 2025Article
Corrections and comments
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Authors and funding
26 authors at 6 institutions in 1 country.
Antentor HintonDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-7730-952X
Prasanna KattiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-6748-3460
Margaret MungaiDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Duane D HallDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Olha KovalDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Jianqiang ShaoCentral Microscopy Research Facility, Iowa City, Iowa, USA.
Zer VueDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Edgar Garza LopezDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Rahmati RostamiDepartment of Genetic Medicine, Joan & Sanford I. Weill Medical College of Cornell University, New York, New York, USA.
Kit NeikirkDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Jessica PonceDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Jennifer StreeterDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Brandon SchicklingDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Serif BacevacDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Chad GrueterDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Andrea MarshallDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Heather K BeasleyDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Young Do KooDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Sue C BodineDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Nayeli G Reyes NavaDepartment of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas, USA.
Anita M QuintanaDepartment of Biological Sciences, Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas, USA.
Long-Sheng SongDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Isabella M GrumbachDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Renata O PereiraDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Brian GlancyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
E Dale AbelDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0001-5290-0738
University of Iowa · USVanderbilt University · USNational Institutes of Health · USThe University of Texas at El Paso · USCornell University · USIowa City Public Library · US
Funding
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MMULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9MDevelopment and Regulation of the Muscle Mitochondrial ReticulumZIAHL006221 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI GLANCY, BRIAN · 2017 to 2025
$14.7MMitochondrial Complex I as a Target for Neuroprotection in ADRF1AG055549 · NIA · MAYO CLINIC ROCHESTER · PI TRUSHINA, EUGENIA · 2017 to 2025
$7.0MPROGRAM IN HEMOSTASIS AND THROMBOSIS FOR ACADEMICT32HL007344 · NHLBI · UNIVERSITY OF IOWA · PI Anil Kumar Chauhan, Steven R Lentz · 1985 to 2026
$6.5MMetabolic Networks and Pathways Predictive of Sex Differences in AD Risk and Responsiveness to TreatmentRF1AG059093 · NIA · DUKE UNIVERSITY · PI BRINTON, ROBERTA EILEEN, CHANG, RUI · 2018 to 2018
$5.9MPRIDE: Functional and Translational Genomics of Blood DisordersR25HL106365 · NHLBI · AUGUSTA UNIVERSITY · PI PACE, BETTY SUE · 2010 to 2024
$5.2MMitochondrial CaMKII drives smooth muscle migration and neointimal hyperplasiaR01HL108932 · NHLBI · UNIVERSITY OF IOWA · PI GRUMBACH, ISABELLA MARIA · 2012 to 2021
$3.6MAMP-Kinase as a target for neuroprotection in ADRF1AG062135 · NIA · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K, TRUSHINA, EUGENIA · 2019 to 2019
$3.2MLeveraging the mitochondrial regulator MIRO1 to prevent neointimal hyperplasiaR01HL157956 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI GRUMBACH, ISABELLA MARIA · 2022 to 2025
$2.4MInflammasome activation in modulation of Alzheimer’s Disease by alcohol Administrative SupplementR01AG072899 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GOLENBOCK, DOUGLAS T, SZABO, GYONGYI · 2020 to 2025
$2.4MSmall molecule mitochondria-targeted therapeutics for Huntingtons DiseaseR01NS107265 · NINDS · MAYO CLINIC ROCHESTER · PI TRUSHINA, EUGENIA · 2018 to 2021
$2.2MIntramural NIH HHS ZIA HL006221NHLBI NIH HHS R01 HL108379NHLBI NIH HHS R01 HL108932NHLBI NIH HHS R01 HL157956NHLBI NIH HHS R25 HL106365NHLBI NIH HHS T32 HL007344NIAMS NIH HHSNIA NIH HHS R01 AG072899NIA NIH HHS RF1 AG055549NIA NIH HHS RF1 AG059093NIA NIH HHS RF1 AG062135NIDDK NIH HHS P30 DK020593NIDDK NIH HHS R01 DK092065NIDDK NIH HHS R01 DK125405NIDDK NIH HHS T32 DK007563NIGMS NIH HHS T32 GM133353NIH HHSNIH HHS T32 5T32GM133353NINDS NIH HHS R01 NS107265
Abstract
Mitochondria and endoplasmic reticulum (ER) contact sites (MERCs) are protein- and lipid-enriched hubs that mediate interorganellar communication by contributing to the dynamic transfer of Ca
Indexed as
Activating Transcription Factor 4Neurodegenerative DiseasesAnimalsCalciumCells, CulturedEndoplasmic ReticulumEndoplasmic Reticulum StressGTP PhosphohydrolasesLipidsMaleMiceMice, Inbred C57BLMitochondriaMuscle, SkeletalActivating Transcription Factor 4Atf4 protein, mouseCalciumGTP PhosphohydrolasesLipidsOpa1 protein, mouseactivating transcription factor 4endoplasmic reticulumintegrated stress responseinterorganelle communicationmitochondria
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.