ArticleJournal of the American Heart Association2024
Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease.
Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 34 citations in OpenAlex.
- Placental Dysfunction and Congenital Heart Disease: Investigating the Placenta-Heart Axis.Prenatal diagnosis · 2026Article
- Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Diminished Late Gestation Placental Volume in Fetal Heart Disease and Implications for Birth Anthropometrics.Journal of cardiovascular development and disease · 2026Article
- Article
- Characterizing placental dysfunction with DNA methylation profiling and placental histopathology.Placenta · 2026Article
- The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease.Prenatal diagnosis · 2026Review
- Placental vascular abnormality is associated with worse neurodevelopmental outcomes for infants with congenital heart disease and genetic abnormality.Early human development · 2026Article
- Environmentally dependent developmental induction as a potential driver of heart evolution.The Journal of experimental biology · 2026Review
- Placental hypoplasia and vascular malperfusion are associated with reduced brain volumes in fetal congenital heart disease.Pediatric research · 2026Article
- Cumulative burden of maternal vascular malperfusion and its association with early cerebral oxygenation in neonates.Frontiers in cell and developmental biology · 2026Article
- Antenatal and Preoperative Factors Associated with 2-Year Outcome of Preterm Newborns with Biventricular Complex Congenital Heart Defects: A 23-Year Cohort Study.Children (Basel, Switzerland) · 2025Article
- Neurodevelopment in congenital heart disease: a review of antenatal mechanisms and therapeutic potentials.Pediatric research · 2025Review
- The "Heart-and-Brain Interaction" in Newborns with Complex Congenital Heart Disease.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Placental and Fetal Brain Volumes in Congenital Heart Disease Are Smallest Among Fetuses With Genetic Abnormalities.Prenatal diagnosis · 2025Article
- Unmasking the Placenta-Heart Axis: A Comprehensive Review of Placental Abnormalities in Congenital Heart Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Cerebral injury and long-term neurodevelopment impairment in children following severe fetomaternal transfusion: a retrospective cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2025Observational
- Cord blood levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 correlate with perinatal brain development in fetal congenital heart disease.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Observational
- Congenital Heart Diseases and Neurodevelopmental Disorders: New Insights Through the DOHaD Hypothesis.JACC. Basic to translational science · 2025Review
- Pregnancy Complications in Fetal Congenital Heart Disease: A Result of Common Early Developmental Pathways Rather Than Fetal Hemodynamics.Prenatal diagnosis · 2025Article
- Placental Inflammation in Preterm Premature Rupture of Membranes and Risk of Neurodevelopmental Disorders.Cells · 2025Review
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonates with congenital heart disease are at risk for impaired brain development in utero, predisposing children to postnatal brain injury and adverse long-term neurodevelopmental outcomes. Given the vital role of the placenta in fetal growth, we assessed the incidence of placental pathology in fetal congenital heart disease and explored its association with total and regional brain volumes, gyrification, and brain injury after birth. METHODS AND
resultsPlacentas from 96 term singleton pregnancies with severe fetal congenital heart disease were prospectively analyzed for macroscopic and microscopic pathology. We applied a placental pathology severity score to relate placental abnormalities to neurological outcome. Postnatal, presurgical magnetic resonance imaging was used to analyze brain volumes, gyrification, and brain injuries. Placental analyses revealed the following abnormalities: maternal vascular malperfusion lesions in 46%, nucleated red blood cells in 37%, chronic inflammatory lesions in 35%, delayed maturation in 30%, and placental weight below the 10th percentile in 28%. Severity of placental pathology was negatively correlated with cortical gray matter, deep gray matter, brainstem, cerebellar, and total brain volumes (
conclusionsPlacental pathology occurs frequently in neonates with severe congenital heart disease and may contribute to impaired brain development, indicated by the association between placental pathology severity and reductions in postnatal cortical, cerebellar, and total brain volumes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.