Evidence map›Paper›PMID 38421132›Full record

ArticleCNS neuroscience & therapeutics2024

Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function.

Fuyi Xu, Anran Chen, Shuijing Pan, Yingying Wu, Hongjie He, Zhe Han, Lu Lu, Buyan-Ochir Orgil, XiaoDong Chi, Cunhua Yang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Fuyi XuShandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.ORCID 0000-0002-5952-5771
Anran ChenThe Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Shuijing PanShandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Yingying WuShandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Hongjie HeShandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Zhe HanShandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Lu LuUniversity of Tennessee Health Science Center, Memphis, Tennessee, USA.
Buyan-Ochir OrgilUniversity of Tennessee Health Science Center, Memphis, Tennessee, USA.
XiaoDong ChiShandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Cunhua YangShandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Shushan JiaDepartment of Anesthesiology, YanTai Affiliated Hospital of BinZhou Medical University, Yantai, China.
Cuicui YuThe Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Jia MiShandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Binzhou Medical University · CNQingdao University · CNUniversity of Tennessee Health Science Center · USBinzhou University · CN

Funding

Binzhou Medical University Research Start-Up 50012304309Binzhou Medical University Research Start-Up 50012304486Major Basic Research Project of Shandong Provincial Natural Science Foundation ZR2019ZD27National Natural Science Foundation of China 32170989Natural Science Foundation of Shandong Province ZR2021MH141Natural Science Foundation of Shandong Province ZR2023MH373Shandong Province Higher Educational Youth Innovation Science and Technology Program 2019KJE013
6 · The paper itself

Abstract

backgroundThere is growing evidence of a strong correlation between pain sensitivity and cognitive function under both physiological and pathological conditions. However, the detailed mechanisms remain largely unknown. In the current study, we sought to explore candidate genes and common molecular mechanisms underlying pain sensitivity and cognitive function with a transcriptome-wide association study using recombinant inbred mice from the BXD family.

methodsThe pain sensitivity determined by Hargreaves' paw withdrawal test and cognition-related phenotypes were systematically analyzed in 60 strains of BXD mice and correlated with hippocampus transcriptomes, followed by quantitative trait locus (QTL) mapping and systems genetics analysis.

resultsThe pain sensitivity showed significant variability across the BXD strains and co-varies with cognitive traits. Pain sensitivity correlated hippocampual genes showed a significant involvement in cognition-related pathways, including glutamatergic synapse, and PI3K-Akt signaling pathway. Moreover, QTL mapping identified a genomic region on chromosome 4, potentially regulating the variation of pain sensitivity. Integrative analysis of expression QTL mapping, correlation analysis, and Bayesian network modeling identified Ring finger protein 20 (Rnf20) as the best candidate. Further pathway analysis indicated that Rnf20 may regulate the expression of pain sensitivity and cognitive function through the PI3K-Akt signaling pathway, particularly through interactions with genes Ppp2r2b, Ppp2r5c, Col9a3, Met, Rps6, Tnc, and Kras.

conclusionsOur study demonstrated that pain sensitivity is associated with genetic background and Rnf20-mediated PI3K-Akt signaling may involve in the regulation of pain sensitivity and cognitive functions.

Indexed as

Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsBayes TheoremCognitionMiceMice, Inbred C57BLPain ThresholdPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktBXD micecognitionhippocampuspain sensitivityRnf20

Identifiers

PMID38421132
PMCPMC10850811
OpenAlexW4391635457

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.