Evidence map›Paper›PMID 38422018›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Dual membrane-spanning anti-sigma factors regulate vesiculation in

Evan J Pardue, Mariana G Sartorio, Biswanath Jana, Nichollas E Scott, Wandy L Beatty, Juan C Ortiz-Marquez, Tim Van Opijnen, Fong-Fu Hsu, Robert F Potter, Mario F Feldman

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. High-throughput analyses ofGut microbes · 2026
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  14. Microbiology spectrum · 2025
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  15. Review
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  19. A molecular toolkit for heterologous protein secretion acrossbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Evan J PardueDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0002-3576-7901
Mariana G SartorioDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0001-5539-2388
Biswanath JanaDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.
Nichollas E ScottDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3000, Australia.ORCID 0000-0003-2556-8316
Wandy L BeattyDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.
Juan C Ortiz-MarquezBiology Department, Boston College, Boston, MA 02467.
Tim Van OpijnenBiology Department, Boston College, Boston, MA 02467.ORCID 0000-0001-6895-6795
Fong-Fu HsuDivision of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0001-5368-0183
Robert F PotterDepartment of Pediatrics, Washington University School of Medicine, Saint Louis, MO 63110.
Mario F FeldmanDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110.
Washington University in St. Louis · USBoston College · USThe University of Melbourne · AU

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI FUMIHIKO URANO · 2013 to 2026
$27.1M
Outer Membrane Vesicles in Human Gut BacteriaR21AI151873 · NIAID · WASHINGTON UNIVERSITY · PI FELDMAN, MARIO · 2020 to 2021
$433k
Biogenesis and functions of outer membrane vesicles in BacteroidetesR21AI168719 · NIAID · WASHINGTON UNIVERSITY · PI FELDMAN, MARIO · 2022 to 2023
$432k
Novel Family of Dual Membrane-Spanning Anti-sigma factors Regulate OMV Biogenesis in Bacteroides thetaiotaomicronF31AI181454 · NIAID · WASHINGTON UNIVERSITY · PI PARDUE, EVAN J · 2024 to 2024
$35k
NIAID NIH HHS F31 AI181454NIAID NIH HHS R21 AI151873NIAID NIH HHS R21 AI168719NIDDK NIH HHS P30 DK020579
6 · The paper itself

Abstract

Bacteroidota are abundant members of the human gut microbiota that shape the enteric landscape by modulating host immunity and degrading dietary- and host-derived glycans. These processes are mediated in part by

Indexed as

Bacteroides thetaiotaomicronHumansPhylogenySigma FactorSigma FactorBacteroidesmicrobiotaregulationsignalingvesicles

Identifiers

PMID38422018
PMCPMC10927553
OpenAlexW4392283566

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.