ArticleScience (New York, N.Y.)2024
Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements.
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In one paragraph
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
What it found
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Who cites it
29 citing papers in PubMed, 32 citations in OpenAlex.
- Functional convergence of regulatory regions provides vital insights into mammalian gliding adaptation.Science China. Life sciences · 2026Article
- Comparative Genomic Screening Identifies Developmental Constraint Loci Underscoring the Phenotypic Evolution of Syngnathids.Integrative zoology · 2026Article
- Review
- The genetic foundations of convergent traits.Nature reviews. Genetics · 2026Review
- The Vertebrate Genomes Project Phase I: A global reference genome resource.bioRxiv : the preprint server for biology · 2026Article
- Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics.bioRxiv : the preprint server for biology · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.Science advances · 2026Article
- Cross-species prediction reveals chromatin regions with increased accessibility in humans.Science advances · 2026Article
- MoleRate: comparing molecular relative evolutionary rates to detect convergent evolution.Evolution; international journal of organic evolution · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.bioRxiv : the preprint server for biology · 2026Article
- Twice times two: Dual mechanism for double rhythmic meter in orangutans and the evolution of human song.iScience · 2026Article
- Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of Birds.Genome biology and evolution · 2025Article
- Phylogenomic Approaches to Study Adaptive Evolution in Mammals: From Aging to Aquatic Lifestyles.Annual review of genetics · 2025Review
- Linking phenotype to genotype using comprehensive genomic comparisons.Current opinion in genetics & development · 2025Review
- Neuronal activity underlying vocal production in bats.Annals of the New York Academy of Sciences · 2025Review
- Integrating Intermediate Traits in Phylogenetic Genotype-to-Phenotype Studies.Integrative and comparative biology · 2025Review
- Vocal Learning Versus Speech Evolution: Untangling a False Equivalence.Ecology and evolution · 2025Article
- Constraint of accessible chromatins maps regulatory loci involved in maize speciation and domestication.Nature communications · 2025Article
- Comparative genomics uncovers evolutionary drivers of locust migratory adaptation.BMC genomics · 2025Article
- Convergent relaxation of molecular constraint in herbivores reveals the changing role of liver and kidney functions across mammalian diets.Genome research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
130 authors at 7 institutions in 1 country.
Morgan E Wirthlin *Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0001-7967-7070
Tobias A Schmid *Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94708, USA.ORCID 0000-0002-0201-433X
Julie E Elie *Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94708, USA.ORCID 0000-0002-7993-0264
Xiaomeng ZhangDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0002-8536-6460
Amanda KowalczykDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0002-9061-1336
Ruby RedlichDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0009-0003-1043-2499
Varvara A ShvarevaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94708, USA.
Ashley RakuljicDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94708, USA.
Maria B JiDepartment of Psychology, University of California, Berkeley, Berkeley, CA 94708, USA.ORCID 0009-0007-1324-3529
Ninad S BhatDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94708, USA.
Irene M KaplowDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0002-8924-8269
Daniel E SchäfferDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0003-3608-152X
Alyssa J LawlerNeuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0002-2151-5164
Andrew Z WangDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0009-0000-1159-6469
BaDoi N PhanDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6331-5980
Siddharth AnnaldasulaDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Ashley R BrownDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3091-3930
Tianyu LuDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Byung Kook LimNeurobiology section, Division of Biological Science, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3766-5415
Eiman AzimMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-1015-1772
Zoonomia Consortium
Nathan L ClarkDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-0006-8374
Wynn K MeyerDepartment of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA.ORCID 0000-0001-7978-3877
Sergei L Kosakovsky PondDepartment of Biology, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0003-4817-4029
Maria ChikinaDepartment of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0003-2550-5403
Michael M Yartsev *Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94708, USA.ORCID 0000-0003-0952-2801
Andreas R Pfenning *Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3447-9801
Gregory Andrews
Joel C Armstrong
Matteo Bianchi
Bruce W Birren
Kevin R Bredemeyer
Ana M Breit
Matthew J Christmas
Hiram Clawson
Joana Damas
Federica Di Palma
Mark Diekhans
Michael X Dong
Eduardo Eizirik
Kaili Fan
Cornelia Fanter
Nicole M Foley
Karin Forsberg-Nilsson
Carlos J Garcia
John Gatesy
Steven Gazal
Diane P Genereux
Linda Goodman
Jenna Grimshaw
Michaela K Halsey
Andrew J Harris
Glenn Hickey
Michael Hiller
Allyson G Hindle
Robert M Hubley
Graham M Hughes
Jeremy Johnson
David Juan
Irene M Kaplow
Elinor K Karlsson
Kathleen C Keough
Bogdan Kirilenko
Klaus-Peter Koepfli
Jennifer M Korstian
Amanda Kowalczyk
Sergey V Kozyrev
Alyssa J Lawler
Colleen Lawless
Thomas Lehmann
Danielle L Levesque
Harris A Lewin
Xue Li
Abigail Lind
Kerstin Lindblad-Toh
Ava Mackay-Smith
Voichita D Marinescu
Tomas Marques-Bonet
Victor C Mason
Jennifer R S Meadows
Wynn K Meyer
Jill E Moore
Lucas R Moreira
Diana D Moreno-Santillan
Kathleen M Morrill
Gerard Muntané
William J Murphy
Arcadi Navarro
Martin Nweeia
Sylvia Ortmann
Austin Osmanski
Benedict Paten
Nicole S Paulat
Andreas R Pfenning
BaDoi N Phan
Katherine S Pollard
Henry E Pratt
David A Ray
Steven K Reilly
Jeb R Rosen
Irina Ruf
Louise Ryan
Oliver A Ryder
Pardis C Sabeti
Daniel E Schäffer
Aitor Serres
Beth Shapiro
Arian F A Smit
Mark Springer
Chaitanya Srinivasan
Cynthia Steiner
Jessica M Storer
Kevin A M Sullivan
Patrick F Sullivan
Elisabeth Sundström
Megan A Supple
Ross Swofford
Joy-El Talbot
Emma Teeling
Jason Turner-Maier
Alejandro Valenzuela
Franziska Wagner
Ola Wallerman
Chao Wang
Juehan Wang
Zhiping Weng
Aryn P Wilder
Morgan E Wirthlin
James R Xue
Xiaomeng Zhang
Carnegie Mellon University · USUniversity of California, Berkeley · USUniversity of Pittsburgh · USLehigh University · USUniversity of California San Diego · USSalk Institute for Biological Studies · USTemple University · US
Funding
Title: Functional Annotation of Genomes via Phenotypic Convergence within Large Multi-species AlignmentsR01HG009299 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria D Chikina, Nathaniel L Clark · 2017 to 2026
$4.1MDefining the anatomical, molecular and functional logic of internal copy circuits involved in dexterous forelimb behaviorsR01NS111479 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2019 to 2023
$2.9MRole of Glutamatergic Neurons in External Globus Pallidus in the Behavioral Deficits in Animal Models of Progressive Dopamine DepletionR01NS121231 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEUTGEB, STEFAN, LIM, BYUNGKOOK · 2021 to 2025
$2.5MDiscovery and characterization of ocular regulatory elements through evolutionary analysisR01EY030546 · NEI · UNIVERSITY OF UTAH · PI CHIKINA, MARIA D, CLARK, NATHANIEL L · 2020 to 2024
$2.4MInterpreting the regulatory mechanisms underlying the predisposition to substance use disordersDP1DA046585 · NIDA · CARNEGIE-MELLON UNIVERSITY · PI PFENNING, ANDREAS ROBERT · 2018 to 2022
$2.4MIntegrating primate-rodent cell types and epigenomics to identify conservation in substance addictionF30DA053020 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PHAN, BADOI NGUYEN · 2021 to 2024
$204kNEI NIH HHS R01 EY030546NHGRI NIH HHS R01 HG009299NIDA NIH HHS DP1 DA046585NIDA NIH HHS F30 DA053020NINDS NIH HHS R01 NS111479NINDS NIH HHS R01 NS121231
Abstract
Vocal production learning ("vocal learning") is a convergently evolved trait in vertebrates. To identify brain genomic elements associated with mammalian vocal learning, we integrated genomic, anatomical, and neurophysiological data from the Egyptian fruit bat (
Indexed as
Enhancer Elements, GeneticEutheriaEvolution, MolecularGene Expression RegulationMotor CortexMotor NeuronsProteinsVocalization, AnimalAmino Acid SequenceAnimalsChiropteraChromatinEpigenesis, GeneticGenomeLarynxMachine LearningChromatinProteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.