Evidence map›Paper›PMID 38422375›Full record

Trial reportSleep2024

Intensive support does not improve positive-airway pressure use in spinal cord injury/disease: a randomized clinical trial.

M Safwan Badr, Jennifer L Martin, Abdulghani Sankari, Salam Zeineddine, Anan Salloum, M Kristina Henzel, Kingman Strohl, Afifa Shamim-Uzzaman, Anna M May, Constance H Fung and 3 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02830074 (Does Treatment of Sleep-Disordered Breathing Improve Functional Outcomes in SCI), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02830074 nacompletednot on this map

Does Treatment of Sleep-Disordered Breathing Improve Functional Outcomes in SCI

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2017 to 2020Enrolled73ConditionsSpinal Cord Injury, Sleep-disordered Breathing, Spinal Cord Disease, Multiple SclerosisArmsBest practices PAP + patient Education +ongoing Support and Training, Sleep Education
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. An update on sleep disordered breathing in spinal cord injury.Current opinion in pulmonary medicine · 2025
    Review
  3. Sleep apnea in individuals with spinal cord injury.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

M Safwan BadrDepartment of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.ORCID 0000-0001-5769-5243
Jennifer L MartinDepartment of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.ORCID 0000-0003-0849-3391
Abdulghani SankariDepartment of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.ORCID 0000-0002-2400-3375
Salam ZeineddineDepartment of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Anan SalloumDepartment of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
M Kristina HenzelGeriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.ORCID 0000-0002-8382-574X
Kingman StrohlDepartment of Medicine, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
Afifa Shamim-UzzamanDepartment of Neurology, VA Ann Arbor Healthcare System.
Anna M MayDepartment of Medicine, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.ORCID 0000-0002-0181-0086
Constance H FungDepartment of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.ORCID 0000-0002-0140-7932
Nishtha PandyaDepartment of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Sean CarrollDepartment of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Michael N MitchellGeriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Wayne State University · USGeriatric Research Education and Clinical Center · USUniversity of California, Los Angeles · USVA Northeast Ohio Healthcare System · USUniversity of Michigan · US

Funding

Sleep health in special populationsK24HL143055 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, JENNIFER L · 2018 to 2025
$898k
Does Treatment of Sleep-Disordered Breathing Improve Functional Outcomes in SCI?I01RX002116 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI BADR, M.SAFWAN · 2017 to 2020
–
Pathogenesis of Sleep Disordered Breathing in Spinal Cord Injury PatientsIK2CX000547 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI SANKARI, ABDULGHANI · 2013 to 2019
–
HSR&D Research Career Scientist AwardIK6HX003160 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI MARTIN, JENNIFER L · 2020 to 2025
–
CSRD VA IK2 CX000547HSRD VA IK6 HX003160NHLBI NIH HHS K24 HL143055RRD VA I01 RX002116
6 · The paper itself

Abstract

STUDY

objectiveTreatment of sleep-disordered breathing (SDB) with positive airway pressure (PAP) therapy has unique clinical challenges in individuals living with spinal cord injuries and diseases (spinal cord injury [SCI]/D). Interventions focused on increasing PAP use have not been studied in this population. We aimed to evaluate the benefits of a program to increase PAP use among Veterans with SCI/D and SDB.

methodsRandomized controlled trial comparing a behavioral Intervention (n = 32) and educational control (n = 31), both including one face-to-face and five telephone sessions over 3 months. The intervention included education about SDB and PAP, goal setting, troubleshooting, and motivational enhancement. The control arm included non-directive sleep education only.

resultsPrimary outcomes were objective PAP use (nights ≥4 hours used within 90 days) and sleep quality (Pittsburgh Sleep Quality Index [PSQI] at 3 months). These did not differ between intervention and control (main outcome timepoint; mean difference 3.5 [-9.0, 15.9] nights/week for PAP use; p = .578; -1.1 [-2.8, 0.6] points for PSQI; p = .219). Secondary outcomes included fatigue, depression, function, and quality of life. Only fatigue improved significantly more in the intervention versus the control group (p = .025). Across groups, more PAP use was associated with larger improvements in sleep quality, insomnia, sleepiness, fatigue, and depression at some time points.

conclusionsPAP use in Veterans with SCI/D and SDB is low, and a 3-month supportive/behavioral program did not show significant benefit compared to education alone. Overall, more PAP use was associated with improved symptoms suggesting more intensive support, such as in-home assistance, may be required to increase PAP use in these patients. CLINICAL TRIALS INFORMATION: Title: "Treatment of Sleep Disordered Breathing in Patients with SCI." Registration number: NCT02830074. Website: https://clinicaltrials.gov/study/NCT02830074?cond=Sleep%20Apnea&term=badr&rank=5.

Indexed as

Sleep Apnea SyndromesSpinal Cord InjuriesVeteransAdultBehavior TherapyContinuous Positive Airway PressureFemaleHumansMaleMiddle AgedPatient Education as TopicSleep QualityTreatment Outcomeadherencepositive-airway pressure therapysleep-disordered breathingspinal cord injury

Identifiers

PMID38422375
PMCPMC11494382
OpenAlexW4392351716

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.