Evidence mapPaperPMID 38422918Full record

ArticleNuclear medicine and biology

Development of a CCR2 targeted

Xiaohui Zhang, Lin Qiu, Debbie H Sultan, Hannah P Luehmann, Yanbo Yu, Xiuli Zhang, Gyu Seong Heo, Alexandria Li, Divangana Lahad, Shinji Rho and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Xiaohui ZhangMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Lin QiuMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Debbie H SultanMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Hannah P LuehmannMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Yanbo YuMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Xiuli ZhangMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Gyu Seong HeoMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Alexandria LiMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Divangana LahadMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Shinji RhoDepartment of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Zhude TuMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Yongjian LiuMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: yongjianliu@wustl.edu.
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · WASHINGTON UNIVERSITY · 2001 to 2025
$19.4M
Molecular Imaging CCR2 Lung Inflammation and FibrosisR01HL151685 · NHLBI · WASHINGTON UNIVERSITY · 2022 to 2025
$3.0M
Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · 2022 to 2025
$2.9M
The PET Radiotracer Translation and Resource Center (PET-RTRC) Training & DisseminationP41EB025815 · WASHINGTON UNIVERSITY · 2025 to 2025
$1.3M
PET Sphingosine-1-Phosphate Receptor 1 (S1P1) radiotracer for inflammation response in multiple sclerosisR01NS103988 · WASHINGTON UNIVERSITY · 2025 to 2025
$625k
NCI NIH HHS P30 CA091842NCI NIH HHS P30CA091842NHLBI NIH HHS R01 HL150891NHLBI NIH HHS R01 HL151685NHLBI NIH HHS R01 HL153436NHLBI NIH HHS R35 HL145212NIBIB NIH HHS P41 EB025815NIH HHS S10 OD018515NIH HHS S10 OD030403NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103988
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory disease and the leading cause of morbidity and mortality worldwide. CC motif chemokine ligand 2 and its corresponding cognate receptor 2 (CCL2/CCR2) signaling has been implicated in regulating monocyte recruitment and macrophage polarization during inflammatory responses that plays a pivotal role in atherosclerosis initiation and progression. In this study, we report the design and synthesis of a novel

Indexed as

AtherosclerosisAnimalsMiceMice, Inbred C57BLMonocytesPositron-Emission TomographyRadiopharmaceuticalsTissue DistributionRadiopharmaceuticals(18)F radiolabelingAtherosclerosisCCR2MacrophagesPET/CT

Identifiers

PMID38422918
PMCPMC10964492
OpenAlexW4392103895

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.