Evidence map›Paper›PMID 38424265›Full record

ArticleMolecular genetics and genomics : MGG2024

Identification of plb1 mutation that extends longevity via activating Sty1 MAPK in Schizosaccharomyces pombe.

Yasukichi Maekawa, Kotaro Matsui, Keisuke Okamoto, Takafumi Shimasaki, Hokuto Ohtsuka, Motohiro Tani, Kunio Ihara, Hirofumi Aiba

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular genetics and genomics : MGG, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Characterization of P-type HMolecular genetics and genomics : MGG · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yasukichi MaekawaLaboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.
Kotaro MatsuiLaboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.
Keisuke OkamotoLaboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.
Takafumi ShimasakiLaboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.ORCID http://orcid.org/0000-0003-2558-9395
Hokuto OhtsukaLaboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.ORCID http://orcid.org/0000-0001-7843-2602
Motohiro TaniDepartment of Chemistry, Faculty of Sciences, Kyushu University, Nishi-ku, Fukuoka, 819-0395, Japan.ORCID http://orcid.org/0000-0003-4316-8260
Kunio IharaCenter for Gene Research, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.ORCID http://orcid.org/0000-0002-1831-3617
Hirofumi AibaLaboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan. aiba@ps.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-7775-0446

Funding

Japan Society for the Promotion of Science JP17H03792Japan Society for the Promotion of Science JP20H02898Japan Society for the Promotion of Science JP23H02125
6 · The paper itself

Abstract

To understand the lifespan of higher organisms, including humans, it is important to understand lifespan at the cellular level as a prerequisite. So, fission yeast is a good model organism for the study of lifespan. To identify the novel factors involved in longevity, we are conducting a large-scale screening of long-lived mutant strains that extend chronological lifespan (cell survival in the stationary phase) using fission yeast. One of the newly acquired long-lived mutant strains (No.98 mutant) was selected for analysis and found that the long-lived phenotype was due to a missense mutation (92Phe → Ile) in the plb1

Indexed as

LysophospholipaseMitogen-Activated Protein KinasesSchizosaccharomycesSchizosaccharomyces pombe ProteinsGene Expression Regulation, FungalLongevityMutationLysophospholipaseMitogen-Activated Protein KinasesSchizosaccharomyces pombe Proteinssty1 protein, S pombeChronological lifespanFission yeastPhospholipase Bplb1 +Schizosaccharomyces pombeSty1 MAPK

Identifiers

PMID38424265

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.