Evidence map›Paper›PMID 38427674›Full record

ArticlePloS one2024

Management of antipsychotics in primary care: Insights from healthcare professionals and policy makers in the United Kingdom.

Alan A Woodall, Aseel S Abuzour, Samantha A Wilson, Frances S Mair, Iain Buchan, Sally B Sheard, Paul Atkinson, Dan W Joyce, Pyers Symon, Lauren E Walker

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Non-pharmacologicaL InterVEntions for Antipsychotic-Induced Weight Gain (RESOLVE) in People Living With Severe Mental Illness: A Realist Synthesis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Antipsychotic management in general practice: serial cross-sectional study (2011-2020).The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
    Article
  10. 'Flattened, fattened, and forgotten': the 'dis-integrated' care of patients prescribed antipsychotics in the UK.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Alan A WoodallDepartment of Primary Care and Mental Health, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0003-2933-0508
Aseel S AbuzourUnit for Ageing and Stroke Research, School of Medicine, University of Leeds, West Yorkshire, United Kingdom.ORCID 0000-0002-4073-4346
Samantha A WilsonDepartment of Public Health, Policy and Systems, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom.
Frances S MairGeneral Practice & Primary Care, School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0001-9780-1135
Iain BuchanNIHR Mental Health Research for Innovation Centre, University of Liverpool, Liverpool, United Kingdom.
Sally B SheardDepartment of Public Health, Policy and Systems, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0001-8116-9120
Paul AtkinsonDepartment of Public Health, Policy and Systems, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0001-8740-6561
Dan W JoyceNIHR Mental Health Research for Innovation Centre, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0002-9433-5340
Pyers SymonDepartment of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.ORCID 0009-0001-6499-8442
Lauren E WalkerDepartment of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0003-1354-0826
University of Liverpool · GBUniversity of Glasgow · GBUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAntipsychotic medication is increasingly prescribed to patients with serious mental illness. Patients with serious mental illness often have cardiovascular and metabolic comorbidities, and antipsychotics independently increase the risk of cardiometabolic disease. Despite this, many patients prescribed antipsychotics are discharged to primary care without planned psychiatric review. We explore perceptions of healthcare professionals and managers/directors of policy regarding reasons for increasing prevalence and management of antipsychotics in primary care.

methodsQualitative study using semi-structured interviews with 11 general practitioners (GPs), 8 psychiatrists, and 11 managers/directors of policy in the United Kingdom. Data was analysed using thematic analysis.

resultsRespondents reported competency gaps that impaired ability to manage patients prescribed antipsychotic medications, arising from inadequate postgraduate training and professional development. GPs lacked confidence to manage antipsychotic medications alone; psychiatrists lacked skills to address cardiometabolic risks and did not perceive this as their role. Communication barriers, lack of integrated care records, limited psychology provision, lowered expectation towards patients with serious mental illness by professionals, and pressure to discharge from hospital resulted in patients in primary care becoming 'trapped' on antipsychotics, inhibiting opportunities to deprescribe. Organisational and contractual barriers between services exacerbate this risk, with socioeconomic deprivation and lack of access to non-pharmacological interventions driving overprescribing. Professionals voiced fears of censure if a catastrophic event occurred after stopping an antipsychotic. Facilitators to overcome these barriers were suggested.

conclusionsPeople prescribed antipsychotics experience a fragmented health system and suboptimal care. Several interventions could be taken to improve care for this population, but inadequate availability of non-pharmacological interventions and socioeconomic factors increasing mental distress need policy change to improve outcomes. The role of professionals' fear of medicolegal or regulatory censure inhibiting antipsychotic deprescribing was a new finding in this study.

Indexed as

Antipsychotic AgentsGeneral PractitionersAdministrative PersonnelDelivery of Health CareHumansPrimary Health CareUnited KingdomAntipsychotic Agents

Identifiers

PMID38427674
PMCPMC10906843
OpenAlexW4392361691

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.