Trial reportClinical autonomic research : official journal of the Clinical Autonomic Research Society2024
Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study.
Trial report in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Prevalence and impact of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Pooled it
- Orthostatic hypotension in Parkinson's disease: effects on clinical features and disease severity-a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Prevalence and incidence of orthostatic hypotension in patients with Parkinson's disease: an updated systematic review and meta-analysis.Frontiers in neurologyPooled it
- Effects of 6 months of endurance exercise on motor function, exercise capacity, and autonomic function based on presence of autonomic dysfunction in individuals with early Parkinson's disease.Journal of Parkinson's disease · 2025Trial
- Cardiovascular pharmacology of dopaminergic agents in humans: a review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Review
- High intensity interval training for Parkinson's disease: A scoping review of systemic effects and physiological adaptations.Journal of Parkinson's disease · 2026Article
- How to treat cardiovascular autonomic failure in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Sympathetic Shift and Insular Alteration: Unravelling the Link Between Anxiety and Heart Rate Variability in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Stage-dependent clinical burden in hospitalized Parkinson's disease with a positive bedside orthostatic hypotension screen: a retrospective cross-sectional analysis.Frontiers in aging neuroscience · 2026Article
- Orthostatic hypotension in Parkinson's disease-More than just lightheadedness and fainting.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Exploring the relationship between orthostatic hypotension and gait in people with Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Approach to Cardiovascular Autonomic Dysfunction in Patients with Synucleinopathies.Movement disorders clinical practice · 2025Review
- The impact of short-term blood pressure variability on cognitive decline in Parkinson's disease patients without co-morbidities.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Acute Pharmacodynamic Effects of Oral Levodopa on Blood Pressure in Parkinson's Disease.Pharmacotherapy · 2025Article
- Risk assessment of the top 50 drugs associated with drug-induced orthostatic hypotension: a disproportionality analysis of the FAERS and JADER databases.Scientific reports · 2025Article
- Wearable multimodal sensing for quantifying the cardiovascular autonomic effects of levodopa in parkinsonism.Frontiers in network physiology · 2025Article
- Orthostatic hypotension in Parkinson's disease: therapeutic considerations.Therapeutic advances in neurological disorders · 2025Review
- HucMSCs-derived Exosomes Protect Against 6-hydroxydopamineinduced Parkinson's Disease in Rats by Inhibiting Caspase-3 Expression and Suppressing Apoptosis.Current stem cell research & therapy · 2025Article
- Advice to People with Parkinson's in My Clinic: Orthostatic Hypotension.Journal of Parkinson's disease · 2024Article
- Association of neurogenic orthostatic hypotension with cognitive decline in Parkinson's disease: a longitudinal cohort study.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe investigated the effect of levodopa on postural blood pressure changes in individuals with Parkinson disease (PD) with (PD
methodsWe performed a prospective randomized crossover study with autonomic testing performed ON and OFF levodopa. The primary outcome was the change in systolic blood pressure (SBP) from supine to 70° tilt at 3 min (ΔSBP-3'). Secondary outcomes included indices of baroreflex function and blood pressure and heart rate during tilt.
resultsWe enrolled 40 individuals with PD (21 PD
conclusionLevodopa decreases blood pressure in both PD with and without autonomic failure, but it does not cause a greater fall in blood pressure from supine to standing at 3 min. Levodopa-induced baroreflex sympathetic noradrenergic impairment may contribute to lower blood pressure. Lower standing blood pressure with levodopa may increase the risks of fall and syncope.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.