ArticleDiabetology & metabolic syndrome2024
Gestational diabetes mellitus aggravates adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy.
Article in Diabetology & metabolic syndrome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- A nomogram integrating dynamic total bile acid monitoring, medication history, and curative effect for preterm birth prediction in twin pregnancies with intrahepatic cholestasis of pregnancy.BMC pregnancy and childbirth · 2026Article
- A nomogram to predict meconium-stained amniotic fluid in patients during labor: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Dose-response association between OGTT and adverse perinatal outcomes after IVF treatment: A cohort study based on a twin population.Journal of endocrinological investigation · 2025Article
- Gestational diabetes complicated with preterm birth: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) with gestational diabetes mellitus (GDM) on perinatal outcomes and establish a prediction model of adverse perinatal outcomes in women with ICP.
methodsThis multicenter retrospective cohort study included the clinical data of 2,178 pregnant women with ICP, including 1,788 women with ICP and 390 co-occurrence ICP and GDM. The data of all subjects were collected from hospital electronic medical records. Univariate and multivariate logistic regression analysis were used to compare the incidence of perinatal outcomes between ICP with GDM group and ICP alone group.
resultsBaseline characteristics of the population revealed that maternal age (p < 0.001), pregestational weight (p = 0.01), pre-pregnancy BMI (p < 0.001), gestational weight gain (p < 0.001), assisted reproductive technology (ART) (p < 0.001), and total bile acid concentration (p = 0.024) may be risk factors for ICP with GDM. Furthermore, ICP with GDM demonstrated a higher association with both polyhydramnios (OR 2.66) and preterm labor (OR 1.67) compared to ICP alone. Further subgroup analysis based on the severity of ICP showed that elevated total bile acid concentrations were closely associated with an increased risk of preterm labour, meconium-stained amniotic fluid, and low birth weight in both ICP alone and ICP with GDM groups. ICP with GDM further worsened these outcomes, especially in women with severe ICP. The nomogram prediction model effectively predicted the occurrence of preterm labour in the ICP population.
conclusionsICP with GDM may result in more adverse pregnancy outcomes, which are associated with bile acid concentrations.
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