Evidence map›Paper›PMID 38430300›Full record

ArticleMolecular and cellular biochemistry2025

P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function.

Marcos Munoz, Christopher Solis, Maximilian McCann, Jooman Park, Koreena Rafael-Clyke, Shamim A K Chowdhury, Yuwei Jiang, Paola C Rosas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marcos MunozDivison of Endocrinology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Christopher SolisDepartment of Health, Nutrition & Food Sciences, Florida State University, Tallahassee, FL, USA.
Maximilian McCannDepartment of Ophthalmology & Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Jooman ParkDepartment of Physiology & Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Koreena Rafael-ClykeDepartment of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Shamim A K ChowdhuryDepartment of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Yuwei JiangDepartment of Physiology & Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Paola C RosasDepartment of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA. prosas@uic.edu.
University of Illinois Chicago · USFlorida State University · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9M
Regulation of beige adipocyte maintenance and its impact on metabolic outcomesR01DK132398 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Yuwei Jiang · 2022 to 2026
$2.6M
P21-activated kinase 1 is a novel regulator of cardiac and adipose tissue function in femalesK01HL155241 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROSAS, PAOLA CECILIA · 2021 to 2025
$864k
Post-translational mechanisms of cardiac adaptation during unloadingR00HL151825 · NHLBI · FLORIDA STATE UNIVERSITY · PI SOLIS OCAMPO, CHRISTOPHER · 2023 to 2025
$747k
American Heart Association CDA849387NHLBI NIH HHS K01 HL155241NHLBI NIH HHS K01HL155241NHLBI NIH HHS R00 HL151825NIDDK NIH HHS DK132398NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK132398
6 · The paper itself

Abstract

While P21-activated kinase-1 (PAK1) has been extensively studied in relation to cardiovascular health and glucose metabolism, its roles within adipose tissue and cardiometabolic diseases are less understood. In this study, we explored the effects of PAK1 deletion on energy balance, adipose tissue homeostasis, and cardiac function utilizing a whole-body PAK1 knockout (PAK1

Indexed as

Adipose TissueEnergy MetabolismHomeostasisMice, Knockoutp21-Activated KinasesSignal TransductionAnimalsHeartMaleMicep21-Activated KinasesPak1 protein, mouseAdipose tissueCardiac functionMetabolismP21-activated kinase-1 (PAK1)Thermogenesis

Identifiers

PMID38430300
PMCPMC11371416
OpenAlexW4392348876

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.