Evidence map›Paper›PMID 38430301›Full record

ReviewMolecular and cellular biochemistry2024

New insights of DsbA-L in the pathogenesis of metabolic diseases.

Siqi Li, Jinfa Wan, Zhenyu Peng, Qiong Huang, Baimei He

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Siqi LiDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Jinfa WanDepartment of Emergency Medicine, Southwest Hospital, Army Medical University, Chongqing, 400038, China.
Zhenyu PengDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Qiong HuangDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Baimei HeDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China. hebaimei@csu.edu.cn.
Xiangya Hospital Central South University · CNCentral South University · CNSecond Xiangya Hospital of Central South University · CNSouthwest Hospital · CN

Funding

Hunan Provincial Natural Science Foundation 2022JJ30832Hunan Provincial Natural Science Foundation 2022JJ30917National Natural Science Foundation of China 81500036Scientific Research Fund of Hunan Provincial Education Department 21B0005Special Fund for Rehabilitation Medicine of the National Clinical Research Center for Geriatric Disorders Clinical Research Fund 2021KFJJ09
6 · The paper itself

Abstract

Metabolic diseases, such as obesity, diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD), are abnormal conditions that result from disturbances of metabolism. With the improvement of living conditions, the morbidity and mortality rates of metabolic diseases are steadily rising, posing a significant threat to human health worldwide. Therefore, identifying novel effective targets for metabolic diseases is crucial. Accumulating evidence has indicated that disulfide bond A oxidoreductase-like protein (DsbA-L) delays the development of metabolic diseases. However, the underlying mechanisms of DsbA-L in metabolic diseases remain unclear. In this review, we will discuss the roles of DsbA-L in the pathogenesis of metabolic diseases, including obesity, diabetes mellitus, and NAFLD, and highlight the potential mechanisms. These findings suggest that DsbA-L might provide a novel therapeutic strategy for metabolic diseases.

Indexed as

Metabolic DiseasesNon-alcoholic Fatty Liver DiseaseAnimalsDiabetes MellitusGlutathione TransferaseHumansObesityGlutathione TransferaseGSTK1 protein, humanDiabetes mellitusDsbA-LMetabolic diseasesNAFLDObesity

Identifiers

PMID38430301
OpenAlexW4392349472

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.