Evidence map›Paper›PMID 38430351›Full record

ArticleMolecular neurobiology2024

Diverse Efficacy of Dimethyl Fumarate in Alleviating the Late Streptozotocin-Induced Cognitive Impairment and Neuropathological Features in Rat.

Irena Majkutewicz, Ewelina Kurowska-Rucińska, Jan Ruciński, Dorota Myślińska, Beata Grembecka, Jagoda Mantej, Katarzyna P Dzik

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Irena MajkutewiczDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland. irena.majkutewicz@ug.edu.pl.ORCID http://orcid.org/0000-0001-6719-3116
Ewelina Kurowska-RucińskaDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Jan RucińskiDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Dorota MyślińskaDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Beata GrembeckaDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Jagoda MantejDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Katarzyna P DzikDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
University of Gdańsk · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous study showed that dimethyl fumarate (DMF) treatment performed within three weeks after intracerebroventricular (ICV) injection of streptozotocin (STZ) attenuated spatial memory impairment, hippocampal neurodegeneration, and neuroinflammation in rats. The present study is aimed at verifying the hypothesis that DMF alleviates late effects of STZ (6 months after ICV injection) which reflects advanced stage of the Alzheimer's disease (AD) in human patients. Spatial memory was assessed with Morris water maze (MWM), general brain level of amyloid β (Aβ) and p-tau was measured by western blot, immunofluorescent labelling of active microglia (IBA1), Aβ and p-tau and histological assay of neurodegeneration (Fluoro-Jade C) were performed in hippocampus and cortex. Two-week oral therapy with DMF normalized spatial memory disrupted by STZ but had no influence on general brain level of Aβ and p-tau. However, immunofluorescence showed local reduction of Aβ aggregates number in parietal cortex and p-tau

Indexed as

Amyloid beta-PeptidesCognitive DysfunctionDimethyl FumarateMicrogliaStreptozocinAnimalsHippocampusMaleRatsRats, Sprague-DawleySpatial Memorytau ProteinsAmyloid beta-PeptidesDimethyl FumarateStreptozocintau ProteinsAlzheimer’s diseaseAmyloidDimethyl fumarateMicrogliap-tauStreptozotocin

Identifiers

PMID38430351
OpenAlexW4392346721

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.