ReviewiScience2024
Fat infiltration in skeletal muscle: Influential triggers and regulatory mechanism.
Review in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 5 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Pooled it
- Sarcopenic obesity and risk of cardio-cerebrovascular disease and mortality: a systematic review and meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Muscle elasticity variations in assessing age-related changes in adults - A systematic review.Geriatrics & gerontology international · 2025Pooled it
- Myosteatosis and the survival of patients with hepatocellular carcinoma: a meta-analysis.Clinical and experimental medicine · 2025Pooled it
- Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review.Acta diabetologica · 2025Pooled it
- The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study.Obesity (Silver Spring, Md.) · 2026Trial
- Effect of Zoledronic Acid on Skeletal Muscle After Bariatric Surgery: A Secondary Analysis From a Randomized Controlled Trial.Obesity (Silver Spring, Md.) · 2026Trial
- Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness.Intensive care medicine · 2025Trial
- Article
- Association of biological age acceleration with muscle aging phenotype in young and middle-aged adults: a prospective cohort study.GeroScience · 2026Article
- The Effects of Incretin Mimetic Therapies on Muscle and Bone Health in Older Adults: A Narrative Review.Obesity (Silver Spring, Md.) · 2026Review
- Vocal Fold Atrophy in an Alzheimer's Disease Rat Model.The Laryngoscope · 2026Article
- Vitamin D status and sarcopenia in older adults: population-based evidence for synergy with diabetes and experimental validation in an aged diabetic rat model.The journal of nutrition, health & aging · 2026Article
- Reference values and cut-points for trunk myopenia and myosteatosis in Chinese adults: a secondary analysis of the China Action on Spine and Hip study.Quantitative imaging in medicine and surgery · 2026Article
- Spatial transcriptomics maps distinct signatures of human intermuscular adipose expansion in mice.medRxiv : the preprint server for health sciences · 2026Article
- GLP-1 Receptor Agonists for Obesity Management in Older Adults: A Scoping Review on the Risk of Sarcopenia and Sarcopenic Obesity.Current nutrition reports · 2026Article
- Unacylated ghrelin counteracts mitochondrial dysfunction and neuromuscular junction disruption in cancer cachexia.American journal of physiology. Cell physiology · 2026Article
- Chronicity and physical activity levels independently associate with spatial patterns of multifidus fat infiltration in chronic low back pain patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Characterization of Genes Related to Intramuscular Fat Deposition in Muscles of Piglets Under Cold Exposure by Whole Transcriptome Sequencing.Current issues in molecular biology · 2026Article
- Feasibility and Reliability of an Automated Muscle Segmentation Pipeline Linking Thoracic Supine Kyphosis and Trunk Muscle-Fat% on CT.Tomography (Ann Arbor, Mich.) · 2026Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fat infiltration in skeletal muscle (also known as myosteatosis) is now recognized as a distinct disease from sarcopenia and is directly related to declining muscle capacity. Hence, understanding the origins and regulatory mechanisms of fat infiltration is vital for maintaining skeletal muscle development and improving human health. In this article, we summarized the triggering factors such as aging, metabolic diseases and metabolic syndromes, nonmetabolic diseases, and muscle injury that all induce fat infiltration in skeletal muscle. We discussed recent advances on the cellular origins of fat infiltration and found several cell types including myogenic cells and non-myogenic cells that contribute to myosteatosis. Furthermore, we reviewed the molecular regulatory mechanism, detection methods, and intervention strategies of fat infiltration in skeletal muscle. Based on the current findings, our review will provide new insight into regulating function and lipid metabolism of skeletal muscle and treating muscle-related diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.