ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2024
[Effects of α1-antitrypsin on motor function in mice with immature brain white matter injury].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors at 1 institution in 1 country.
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Abstract
objectivesTo investigate the effects of α1-antitrypsin (AAT) on motor function in adult mice with immature brain white matter injury.
methodsFive-day-old C57BL/6J mice were randomly assigned to the sham surgery group (
resultsCompared to the sham surgery group, mice with HI injury showed high signal intensity on brain T2-weighted magnetic resonance imaging at 7 days after modeling, indicating significant white matter injury. The white matter injury persisted at 55 days after modeling. In comparison to the sham surgery group, the HI+saline group exhibited decreased paw print area, maximum contact area, average pressure, maximum pressure, paw print width, average velocity, body velocity, stride length, swing speed, percentage of gait pattern AA, and percentage of inter-limb coordination (left hind paw → left front paw) (
conclusionsThe mice with immature brain white matter injury may exhibit significant motor dysfunction in adulthood, while the use of AAT can improve some aspects of their motor function.
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