ArticleProceedings of the National Academy of Sciences of the United States of America2024
Reply to Kaestner et al.: Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine.
Abstract readComment
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Supercooled storage of red blood cells slows down the metabolic storage lesion.Scientific reports · 2025Article
- Multi-task machine learning for transfusion decision support in acute upper gastrointestinal bleeding: a novel ensemble approach with clinical validation.Journal of translational medicine · 2025Article
- Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance.The Journal of clinical investigation · 2025Article
Corrections and comments
- Comment on
Authors and funding
17 authors.
Ziya IsiksacanDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.ORCID 0000-0002-4125-4432
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045.ORCID 0000-0002-2258-6490
David H McKennaDivision of Transfusion Medicine, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455.ORCID 0000-0001-8734-0996
Shannon N TessierDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.ORCID 0000-0003-2373-232X
Erdem KucukalBioChip Labs, Cleveland, OH 44195.
A Aslihan GokaltunDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.ORCID 0000-0002-5880-0049
Nishaka WilliamLaboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R8, Canada.
Rebecca D SandlinDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
John BischofDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455.
Narla MohandasNew York Blood Center, New York, NY 10065.ORCID 0000-0003-2271-5296
Michael P BuschVitalant Research Institute, San Francisco, CA 94105.ORCID 0000-0002-1446-125X
Caglar ElbukenInstitute of Materials Science and Nanotechnology, National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.ORCID 0000-0001-8359-6871
Umut A GurkanDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0002-0331-9960
Mehmet TonerDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
Jason P AckerLaboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R8, Canada.ORCID 0000-0002-1445-827X
Martin L YarmushDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
O Berk UstaDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.ORCID 0000-0001-9328-568X
Funding
The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9MThe role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4MThe paradoxical response to iron in pulmonary hypertension of sickle cell diseaseR01HL161004 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUEHLER, PAUL WERNER, D'ALESSANDRO, ANGELO · 2022 to 2025
$2.7MInteractions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6MDeep Supercooling of Red Blood Cells: Towards Practical Long Term StorageR01HL145031 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI USTA, OSMAN BERK, YARMUSH, MARTIN L · 2020 to 2023
$1.5MHigh Quality Long Term Preservation of Sporozoites via Deep SupercoolingR21AI142415 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SANDLIN, REBECCA, USTA, OSMAN BERK · 2019 to 2020
$462kCryopreservation of functional neutrophils by vitrificationR21AI163950 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SANDLIN, REBECCA · 2021 to 2022
$462kDeep Supercooling of Liver Cells and 2D and 3D Tissue Constructs: Effect of AttachmentR21GM136002 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI USTA, OSMAN BERK · 2019 to 2020
$462kEarly Toxicity Detection Technologies via Exosomal Signatures in 3D Hepatic TissuesR21GM140656 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI USTA, OSMAN BERK · 2022 to 2023
$462kNHLBI NIH HHS R01 HL145031NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714NHLBI NIH HHS R01 HL161004NIAID NIH HHS R21 AI142415NIAID NIH HHS R21 AI163950NIGMS NIH HHS R21 GM136002NIGMS NIH HHS R21 GM140656
Abstract
PubMed holds no abstract for this paper.
Indexed as
Transfusion MedicinePrecision Medicine
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What Socratic holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.