Evidence map›Paper›PMID 38438485›Full record

Observational studyScientific reports2024

Effects of acute phase intensive electrical muscle stimulation in COVID-19 patients requiring invasive mechanical ventilation: an observational case-control study.

Yohei Tsuchikawa, Shinya Tanaka, Daisuke Kasugai, Riko Nakagawa, Miho Shimizu, Takayuki Inoue, Motoki Nagaya, Takafumi Nasu, Norihito Omote, Michiko Higashi and 4 more

Open access · goldAbstract readObservational Study

PubMed Full text at PMC Publisher

In one paragraph

Observational study in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.8field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Medium-Frequency Neuromuscular Electrical Stimulation in Critically Ill Patients Promoted Larger Functional Capacity Improvement During Recovery than Low-Frequency Neuromuscular Electrical Stimulation: Randomized Clinical Trial.Journal of clinical medicine · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yohei Tsuchikawa *Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan.

Shinya Tanaka *Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan.

Daisuke KasugaiDepartment of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Riko NakagawaDepartment of Rehabilitation, Nagoya University Hospital, Nagoya, Japan.

Miho ShimizuDepartment of Rehabilitation, Mie University Hospital, Tsu, Japan.

Takayuki InoueDepartment of Rehabilitation, Nagoya University Hospital, Nagoya, Japan.

Motoki NagayaDepartment of Rehabilitation, Nagoya University Hospital, Nagoya, Japan.

Takafumi NasuDepartment of Rehabilitation, Juko Osu Hospital, Nagoya, Japan.

Norihito OmoteDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Michiko HigashiDepartment of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Takanori YamamotoDepartment of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Naruhiro JingushiDepartment of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Atsushi NumaguchiDepartment of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Yoshihiro NishidaDepartment of Rehabilitation, Nagoya University Hospital, Nagoya, Japan. ynishida@med.nagoya-u.ac.jp.

Nagoya University · JPNagoya University Hospital · JPMie University Hospital · JP

Funding

Japan Society for the Promotion of Science Grant-in-Aid 20K19375

6 · The paper itself

Abstract

We investigated the effects of acute-phase intensive electrical muscle stimulation (EMS) on physical function in COVID-19 patients with respiratory failure requiring invasive mechanical ventilation (IMV) in the intensive care unit (ICU). Consecutive COVID-19 patients requiring IMV admitted to a university hospital ICU between January and April 2022 (EMS therapy group) or between March and September 2021 (age-matched historical control group) were included in this retrospective observational case-control study. EMS was applied to both upper and lower limb muscles for up to 2 weeks in the EMS therapy group. The study population consisted of 16 patients undergoing EMS therapy and 16 age-matched historical controls (median age, 71 years; 81.2% male). The mean period until initiation of EMS therapy after ICU admission was 3.2 ± 1.4 days. The EMS therapy group completed a mean of 6.2 ± 3.7 EMS sessions, and no adverse events occurred. There were no significant differences between the two groups in Medical Research Council sum score (51 vs. 53 points, respectively; P = 0.439) or ICU mobility scale at ICU discharge. Addition of upper and lower limb muscle EMS therapy to an early rehabilitation program did not result in improved physical function at ICU discharge in severe COVID-19 patients.

Indexed as

COVID-19Respiration, ArtificialAgedCase-Control StudiesFemaleHumansMaleMusclesRetrospective StudiesIntensive care unit acquired weaknessNeuromuscular electrical stimulationPhysical performanceSARS-CoV-2Ventilator

Identifiers

PMID38438485

DOI10.1016/j.jclinepi.2006.03.012

PMCPMC10912433

OpenAlexW4392362135

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.