Evidence map›Paper›PMID 38438535›Full record

ArticleScientific reports2024

Craniofacial bone anomalies related to cholesterol synthesis defects.

Chihiro Iwaya, Akiko Suzuki, Junbo Shim, Aemin Kim, Junichi Iwata

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chihiro IwayaDepartment of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center at Houston (UTHealth), School of Dentistry, 1941 East Road, BBS 4208, Houston, TX, 77054, USA.
Akiko SuzukiDepartment of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center at Houston (UTHealth), School of Dentistry, 1941 East Road, BBS 4208, Houston, TX, 77054, USA.
Junbo ShimDepartment of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center at Houston (UTHealth), School of Dentistry, 1941 East Road, BBS 4208, Houston, TX, 77054, USA.
Aemin KimDepartment of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center at Houston (UTHealth), School of Dentistry, 1941 East Road, BBS 4208, Houston, TX, 77054, USA.
Junichi IwataDepartment of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center at Houston (UTHealth), School of Dentistry, 1941 East Road, BBS 4208, Houston, TX, 77054, USA. Junichi.Iwata@uth.tmc.edu.
The University of Texas Health Science Center at Houston · USThe University of Texas Health Science Center · USUniversity of Missouri–Kansas City · US

Funding

NIDCR NIH HHS R01 DE026767NIDCR NIH HHS R01DE026767NIDCR NIH HHS R01 DE029818
6 · The paper itself

Abstract

DHCR7 and SC5D are enzymes crucial for cholesterol biosynthesis, and mutations in their genes are associated with developmental disorders, which are characterized by craniofacial deformities. We have recently reported that a loss of either Dhcr7 or Sc5d results in a failure in osteoblast differentiation. However, it remains unclear to what extent a loss of function in either DHCR7 or SC5D affects craniofacial skeletal formation. Here, using micro computed tomography (μCT), we found that the bone phenotype differs in Dhcr7

Indexed as

Musculoskeletal AbnormalitiesAnimalsCell DifferentiationCholesterolLipid MetabolismMiceX-Ray MicrotomographyCholesterol

Identifiers

PMID38438535
PMCPMC10912708
OpenAlexW4392384700

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.