ArticleCardiovascular engineering and technology2024
Impact of Pressure Guidewire on Model-Based FFR Prediction.
Article in Cardiovascular engineering and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Multimodality catheter composed of intravascular ultrasound imaging and polymer optical fiber FFR functions for the diagnosis of cardiac disease.Biomedical optics express · 2026Article
- Modeling cardiac microcirculation for the simulation of coronary flow and 3D myocardial perfusion.Biomechanics and modeling in mechanobiology · 2024Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFractional Flow Reserve (FFR) is used to characterize the functional significance of coronary artery stenoses. FFR is assessed under hyperemic conditions by invasive measurements of trans-stenotic pressure thanks to the insertion of a pressure guidewire across the coronary stenosis during catheterization. In order to overcome the potential risk related to the invasive procedure and to reduce the associated high costs, three-dimensional blood flow simulations that incorporate clinical imaging and patient-specific characteristics have been proposed. PURPOSE: Most CCTA-derived FFR models neglect the potential influence of the guidewire on computed flow and pressure. Here we aim to quantify the impact of taking into account the presence of the guidewire in model-based FFR prediction.
methodsWe adopt a CCTA-derived FFR model and perform simulations with and without the guidewire for 18 patients with suspected stable CAD.
resultsPresented results show that the presence of the guidewire leads to a tendency to predict a lower FFR value. The FFR reduction is prominent in cases of severe stenoses, while the influence of the guidewire is less pronounced in cases of moderate stenoses.
conclusionFrom a clinical decision-making point of view, including of the pressure guidewire is potentially relevant only for intermediate stenosis cases.
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