Evidence map›Paper›PMID 38438768›Full record

ArticleStem cell reviews and reports2024

Complementary and Inducible creER

Michael G Poulos, Pradeep Ramalingam, Agatha Winiarski, Michael C Gutkin, Lizabeth Katsnelson, Cody Carter, Laurence Pibouin-Fragner, Anne Eichmann, Jean-Leon Thomas, Lucile Miquerol and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Stem cell reviews and reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Deep imaging of LepRBone research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Michael G PoulosDepartment of Medicine, University of Florida Health Cancer Center, Gainesville, FL, 32610, USA.ORCID 0000-0002-7622-9966
Pradeep RamalingamDepartment of Medicine, University of Florida Health Cancer Center, Gainesville, FL, 32610, USA.ORCID 0000-0002-5943-9670
Agatha WiniarskiDepartment of Medicine, University of Florida Health Cancer Center, Gainesville, FL, 32610, USA.
Michael C GutkinAnsary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA.
Lizabeth KatsnelsonAnsary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA.
Cody CarterDepartment of Medicine, University of Florida Health Cancer Center, Gainesville, FL, 32610, USA.
Laurence Pibouin-FragnerUniversité de Paris Cité, Inserm, PARCC, 75015, Paris, France.
Anne EichmannUniversité de Paris Cité, Inserm, PARCC, 75015, Paris, France.
Jean-Leon ThomasDepartment of Neurology, Yale University School of Medicine, New Haven, CT, 06511, USA.
Lucile MiquerolAix-Marseille Université, CNRS UMR 7288, IBDM, 13288, Marseille, France.
Jason M ButlerDepartment of Medicine, University of Florida Health Cancer Center, Gainesville, FL, 32610, USA. jason.butler@medicine.ufl.edu.ORCID 0000-0001-6671-3159
University of Florida Health · USCornell University · USInserm · FRCentre National de la Recherche Scientifique · FRYale University · US

Funding

Rejuvenation of aged hematopoietic stem cells and endothelial niches by thrombospondin-1 blockadeR01AG065436 · NIA · UNIVERSITY OF FLORIDA · PI BUTLER, JASON MATHEW · 2019 to 2023
$2.9M
Preserving bone marrow niche integrity and function to rejuvenate aged hematopoietic stem cellsR01HL166512 · NHLBI · UNIVERSITY OF FLORIDA · PI Jason Mathew Butler · 2023 to 2026
$2.5M
Modulating signaling pathways in endothelial cells to abate leukemic progression.R01CA204308 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTLER, JASON MATHEW · 2016 to 2020
$2.0M
Modulating endothelial-specific signaling to enhance functional hematopoiesis.R01HL133021 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTLER, JASON MATHEW · 2016 to 2019
$1.7M
NCI NIH HHS R01 CA204308NCI NIH HHS R01CA204308NHLBI NIH HHS R01 HL133021NHLBI NIH HHS R01HL133021NHLBI NIH HHS R01 HL166512NHLBI NIH HHS R01HL166512NIA NIH HHS R01 AG065436NIA NIH HHS R01AG065436
6 · The paper itself

Abstract

In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of the hematopoietic stem cell (HSC)-supportive niche, which modulates HSC activity by producing secreted and membrane-bound paracrine signals. Within the BM, distinct vascular arteriole, transitional, and sinusoidal EC subtypes display unique paracrine expression profiles and create anatomically-discrete microenvironments. However, the relative contributions of vascular endothelial subtypes in supporting hematopoiesis is unclear. Moreover, constitutive expression and off-target activity of currently available endothelial-specific and endothelial-subtype-specific murine cre lines potentially confound data analysis and interpretation. To address this, we describe two tamoxifen-inducible cre-expressing lines, Vegfr3-creER

Indexed as

Endothelial CellsIntegrasesTamoxifenAnimalsBone MarrowBone Marrow CellsHematopoiesisHematopoietic Stem CellsMiceMice, TransgenicCre recombinaseIntegrasesTamoxifenArterioleBone Marrow NicheCre ModelsEndothelial CellHematopoietic Stem CellSinusoid

Identifiers

PMID38438768
PMCPMC11087254
OpenAlexW4392381259

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.