ArticleMolecular genetics and genomics : MGG2024
Genomics-based analysis of four porcine-derived lactic acid bacteria strains and their evaluation as potential probiotics.
Article in Molecular genetics and genomics : MGG, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Phenotypic, Genomic, and In Vivo Characterization of a Host-Derived Limosilactobacillus fermentum RLF77 with Potential to Prevent Post-weaning Diarrhea in Rabbits.Probiotics and antimicrobial proteins · 2026Article
- Comparative Study on Biological Characteristics and Functions of Three Porcine-Derived Lactic Acid Bacteria.Animals : an open access journal from MDPI · 2026Article
- Genomic architecture and transcriptional regulation of cellulose degradation in the novel marine bacterium Pseudoxanthomonas sp. JC1303.Molecular genetics and genomics : MGG · 2026Article
- Swine-Derived Probiotics and Their Metabolites as an Alternative to Veterinary Antibiotics.Veterinary sciences · 2025Review
- Genomic and stress resistance characterization ofMicrobiology spectrum · 2025Article
- Multi-Strain Probiotic Regulates the Intestinal Mucosal Immunity and Enhances the Protection of Piglets Against Porcine Epidemic Diarrhea Virus Challenge.Microorganisms · 2025Article
- In Situ Cross-Linked Porous Starch Microencapsulation Enhances the Colonization ofFoods (Basel, Switzerland) · 2025Article
- Screening and evaluation of purines-degrading lactic acid bacteria isolated from traditional fermented foods in Yunnan Province and their uric acid-lowering effectsFrontiers in microbiology · 2025Article
- Isolation, Genomics-Based and Biochemical Characterization of Bacteriocinogenic Bacteria and Their Bacteriocins, Sourced from the Gastrointestinal Tract of Meat-Producing Pigs.International journal of molecular sciences · 2024Article
- Associations between intestinal lactic acid bacteria species and feeding habits of zoo animals.Microbiome research reports · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The search for probiotics and exploration of their functions are crucial for livestock farming. Recently, porcine-derived lactic acid bacteria (LAB) have shown great potential as probiotics. However, research on the evaluation of porcine-derived LAB as potential probiotics through genomics-based analysis is relatively limited. The present study analyzed four porcine-derived LAB strains (Lactobacillus johnsonii L16, Latilactobacillus curvatus ZHA1, Ligilactobacillus salivarius ZSA5 and Ligilactobacillus animalis ZSB1) using genomic techniques and combined with in vitro tests to evaluate their potential as probiotics. The genome sizes of the four strains ranged from 1,897,301 bp to 2,318,470 bp with the GC contents from 33.03 to 41.97%. Pan-genomic analysis and collinearity analysis indicated differences among the genomes of four strains. Carbohydrate active enzymes analysis revealed that L. johnsonii L16 encoded more carbohydrate active enzymes than other strains. KEGG pathway analysis and in vitro tests confirmed that L. johnsonii L16 could utilize a wide range of carbohydrates and had good utilization capacity for each carbohydrate. The four strains had genes related to acid tolerance and were tolerant to low pH, with L. johnsonii L16 showing the greatest tolerance. The four strains contained genes related to bile salt tolerance and were able to tolerate 0.1% bile salt. Four strains had antioxidant related genes and exhibited antioxidant activity in in vitro tests. They contained the genes linked with organic acid biosynthesis and exhibited antibacterial activity against enterotoxigenic Escherichia coli K88 (ETEC K88) and Salmonella 6,7:c:1,5, wherein, L. johnsonii L16 and L. salivarius ZSA5 had gene clusters encoding bacteriocin. Results suggest that genome analysis combined with in vitro tests is an effective approach for evaluating different strains as probiotics. The findings of this study indicate that L. johnsonii L16 has the potential as a probiotic strain among the four strains and provide theoretical basis for the development of probiotics in swine production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.