Evidence map›Paper›PMID 38438918›Full record

ArticleImplementation science : IS2024

Evidence-based Medication knowledge Brokers in Residential Aged CarE (EMBRACE): protocol for a helix-counterbalanced randomised controlled trial.

J Simon Bell, Adam La Caze, Michelle Steeper, Terry P Haines, Sarah N Hilmer, Lakkhina Troeung, Lyntara Quirke, Jacqueline Wesson, Constance Dimity Pond, Laurie Buys and 13 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Implementation science : IS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 1 country.

J Simon BellCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville Campus, Parkville, VIC, 3052, Australia. simon.bell2@monash.edu.
Adam La CazeSchool of Pharmacy, The University of Queensland, Dutton Park, QLD, Australia.
Michelle SteeperCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville Campus, Parkville, VIC, 3052, Australia.
Terry P HainesFaculty of Medicine Nursing and Health Sciences, School of Primary and Allied Health Care, Monash University, Clayton, VIC, Australia.
Sarah N HilmerKolling Institute, Faculty of Medicine and Health, The University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia.
Lakkhina TroeungBrightwater Research Centre, Brightwater Care Group, Inglewood, WA, Australia.
Lyntara QuirkeDementia Australia, Canberra, Australia.
Jacqueline WessonAgeing and Health Research Unit, Discipline of Occupational Therapy, Faculty of Medicine and Health, Sydney School of Health Sciences, University of Sydney, Camperdown, NSW, Australia.
Constance Dimity PondWicking Dementia Research and Teaching Centre, University of Tasmania, Hobart, TAS, Australia.
Laurie BuysFaculty of Health Sciences, Australian Catholic University, Brisbane, QLD, Australia.
Nazanin Ghahreman-FalconerSchool of Pharmacy, The University of Queensland, Dutton Park, QLD, Australia.
Michael T LawlessCaring Futures Institute, College of Nursing and Health Sciences, Flinders University, Bedford Park, Adelaide, South Australia, Australia.
Shakti ShresthaSchool of Pharmacy, The University of Queensland, Dutton Park, QLD, Australia.
Angelita MartiniBrightwater Research Centre, Brightwater Care Group, Inglewood, WA, Australia.
Nancy OchiengLifeview Corporate Lifeview Pty Ltd., Carnegie, VIC, Australia.
Francesca GlamorganMontefiore, Randwick, NSW, Australia.
Carmela LagascaAnglicare Southern Queensland, Fortitude Valley, QLD, Australia.
Rebecca WaltonBrightwater Research Centre, Brightwater Care Group, Inglewood, WA, Australia.
Dayna CeninBrightwater Research Centre, Brightwater Care Group, Inglewood, WA, Australia.
Alison KitsonCaring Futures Institute, College of Nursing and Health Sciences, Flinders University, Bedford Park, Adelaide, South Australia, Australia.
Monica JungCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville Campus, Parkville, VIC, 3052, Australia.
Alexandra BennettNew South Wales Therapeutic Advisory Group, Sydney, NSW, Australia.
Amanda J CrossCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville Campus, Parkville, VIC, 3052, Australia. amanda.cross@monash.edu.ORCID 0000-0001-6001-9211
Monash University · AUThe University of Queensland · AUFlinders University · AUThe University of Sydney · AUAustralian Catholic University · AUDementia Australia · AUUniversity of Tasmania · AU

Funding

Australian Government Medical Research Future Fund GA187306National Health and Medical Research Council Emerging Leadership 1 grant (APP2009633)
6 · The paper itself

Abstract

introductionClinical practice guidelines recommend against the routine use of psychotropic medications in residential aged care facilities (RACFs). Knowledge brokers are individuals or groups who facilitate the transfer of knowledge into practice. The objective of this trial is to evaluate the effectiveness and cost-effectiveness of using knowledge brokers to translate Australia's new Clinical Practice Guidelines for the Appropriate Use of Psychotropic Medications in People Living with Dementia and in Residential Aged Care. METHODS AND ANALYSIS: The Evidence-based Medication knowledge Brokers in Residential Aged CarE (EMBRACE) trial is a helix-counterbalanced randomised controlled trial. The 12-month trial will be conducted in up to 19 RACFs operated by four Australian aged care provider organisations in Victoria, New South Wales, Western Australia and Queensland. RACFs will be randomised to receive three levels of implementation strategies (knowledge broker service, pharmacist-led quality use of medications education activities and distribution of the Guidelines and supporting materials) across three medication contexts (antipsychotics, benzodiazepines and antidepressants). Implementation strategies will be delivered by an embedded on-site aged care pharmacist working at a system level across each participating RACF. All RACFs will receive all implementation strategies simultaneously but for different medication contexts. The primary outcome will be a composite dichotomous measure of 6-month RACF-level concordance with Guideline recommendations and good practice statements among people using antipsychotics, benzodiazepines and antidepressants for changed behaviours. Secondary outcomes will include proportion of residents with Guideline concordant use of antipsychotics, benzodiazepines and antidepressants measured at the RACF-level and proportion of residents with psychotropic medication use, hospitalisation, falls, falls with injury, polypharmacy, quality of life, activities of daily living, medication incidents and behavioural incidents measured at the RACF-level. DISCUSSION: The EMBRACE trial investigates a novel guideline implementation strategy to improve the safe and effective use of psychotropic medications in RACFs. We anticipate that the findings will provide new information on the potential role of knowledge brokers for successful and cost-effective guideline implementation.

trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12623001141639. Registered 6 November 2023 - retrospectively registered, https://www.anzctr.org.au/TrialSearch.aspx .

Indexed as

Activities of Daily LivingAntipsychotic AgentsAgedAntidepressive AgentsBenzodiazepinesHumansQuality of LifeRandomized Controlled Trials as TopicVictoriaAntidepressive AgentsAntipsychotic AgentsBenzodiazepinesDementiaEvidence-based practiceImplementation scienceImplementation strategiesInappropriate prescribingLong-term carePractice guidelines as topicPsychotropic drugsRandomised controlled trialResidential facilities

Identifiers

PMID38438918
PMCPMC10913248
OpenAlexW4392382282

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.