Evidence map›Paper›PMID 38440696›Full record

ArticleIJU case reports2024

A case of complete response to avelumab plus axitinib combination therapy for metastatic clear cell renal cell carcinoma in a kidney undergoing dialysis.

Ei Shiomi, Yuta Goto, Mizuki Hisano, Rento Ito, Makoto Moriwaka, Daiki Ikarashi, Shigekatsu Maekawa, Renpei Kato, Mitsugu Kanehira, Takashi Ujiie and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in IJU case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ei ShiomiDepartment of Urology Iwate Medical University Yahaba Iwate Japan.ORCID https://orcid.org/0000-0002-7221-4628
Yuta GotoDepartment of Urology Iwate Prefectural Ofunato Hospital Ofunato Iwate Japan.
Mizuki HisanoDepartment of Urology Iwate Prefectural Ofunato Hospital Ofunato Iwate Japan.ORCID https://orcid.org/0000-0002-4958-302X
Rento ItoDepartment of Urology Iwate Medical University Yahaba Iwate Japan.
Makoto MoriwakaDepartment of Urology Iwate Medical University Yahaba Iwate Japan.
Daiki IkarashiDepartment of Urology Iwate Medical University Yahaba Iwate Japan.ORCID https://orcid.org/0000-0001-8088-2848
Shigekatsu MaekawaDepartment of Urology Iwate Medical University Yahaba Iwate Japan.ORCID https://orcid.org/0000-0003-4620-2831
Renpei KatoDepartment of Urology Iwate Medical University Yahaba Iwate Japan.
Mitsugu KanehiraDepartment of Urology Iwate Medical University Yahaba Iwate Japan.ORCID https://orcid.org/0000-0001-8811-8158
Takashi UjiieDepartment of Urology Iwate Prefectural Ofunato Hospital Ofunato Iwate Japan.
Wataru ObaraDepartment of Urology Iwate Medical University Yahaba Iwate Japan.ORCID https://orcid.org/0000-0003-2720-9640
Iwate Medical University · JPIwate Prefectural Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Combination therapies of immune checkpoint and tyrosine kinase inhibitors for end-stage kidney disease and patients on hemodialysis need careful consideration as few case reports provide suitable management decisions. Case presentation: A 70-year-old man who had undergone hemodialysis for 6 years due to nephrosclerosis. Avelumab plus axitinib combination therapy was performed for repeated lung metastasis, and a complete response was achieved without major side effects. Conclusion: A complete response was achieved after Ave plus Axi combination therapy for clear cell renal cell carcinoma in a patient undergoing dialysis. This suggests that Ave plus Axi combination therapy may be safe and effective for dialysis patients.

Indexed as

avelumabaxitinibcarcinomaimmune checkpoint inhibitorsrenal cellrenal dialysis

Identifiers

PMID38440696
PMCPMC10909135
OpenAlexW4390699786

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.