ReviewDeutsches Arzteblatt international2024
Perioperative Antibiotic Prophylaxis—Indications and Modalities for the Prevention of Postoperative Wound Infection.
Review in Deutsches Arzteblatt international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Clinical Practice Guideline: Recommendations for the Perioperative Management of Pancreatic and Colorectal Cancer Patients.Deutsches Arzteblatt international · 2024Guideline
- Compliance with preoperative antibiotic prophylaxis in cesarean delivery and its impact on surgical site infections: A national retrospective study of Jordan.Global health research and policy · 2026Article
- Safety of routine antimicrobial prophylaxis for surgery (SAPPHIRE): a prospective multi-centre cohort study.EClinicalMedicine · 2026Article
- Is Less More? The Need of Perioperative Antibiotic Prophylaxis and Burying K-Wires in Pediatric Trauma Surgery-A Retrospective Analysis of 779 Distal Forearm and Distal Humeral Osteosyntheses.Children (Basel, Switzerland) · 2026Article
- Administration Routes for Perioperative Prophylactic Antibiotics: A Scoping Review of Intravenous Push Versus Infusion.Antibiotics (Basel, Switzerland) · 2026Review
- Article
- Is Perioperative Antibiotic Prophylaxis Necessary for Pediatric and Adolescent ESIN Osteosyntheses?-A Retrospective Analysis of 939 Surgical Procedures.Children (Basel, Switzerland) · 2026Article
- Perioperative Antimicrobial Prophylaxis in Elective and High-Risk Laparoscopic Cholecystectomy: A Narrative Review.Cureus · 2026Review
- Perioperative nursing process-oriented bundled interventions and digital monitoring for the prevention of surgical site infections.Frontiers in medicine · 2026Review
- Length and Type of Antibiotic Prophylaxis for Infection Prevention in Adults Patient in the Cardiac Surgery Intensive Care Unit: A Narrative Review.Antibiotics (Basel, Switzerland) · 2025Review
- The Impact of Antibiotic Prophylaxis on Antibiotic Resistance, Clinical Outcomes, and Costs in Adult Hemato-Oncological and Surgical Patients: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2025Review
- Periocular Reconstruction in Facial Trauma: Surgical Approaches and Multidisciplinary Perspectives.Cureus · 2025Review
- Important aspects of the multimodal perioperative management in gynecology.Archives of gynecology and obstetrics · 2025Review
- Cervical Infection as a Novel Risk Factor for Perineal Obstetrical Trauma: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Important issues on the prevention of surgical site infections and the management of prophylactic antibiotics.World journal of gastrointestinal surgery · 2025Article
- [Prevention and treatment of surgical site infections in abdominal surgery].Chirurgie (Heidelberg, Germany) · 2025Review
- [Perioperative antibiotic prophylaxis in obesity].Orthopadie (Heidelberg, Germany) · 2025Review
- In Reply.Deutsches Arzteblatt international · 2025Article
- Valid Concerns.Deutsches Arzteblatt international · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative surgical site infections (SSI) account for almost 25% of all nosocomial infections in Germany and are a source of increased morbidity and mortality.
methodsThis review is based on pertinent publications retrieved by a selective search in PubMed and on national and international guidelines.
resultsThe individual risk factors for SSI must be assessed before any surgical procedure. A body-mass index above 30 kg/m2 is associated with an unadjusted risk ratio of 1.35 [1.28; 1.41] for SSI, which rises to 3.29 [2.99; 3.62] if the patient is also immunosuppressed. The risk of SSI is also significantly higher with certain types of procedure. Perioperative antibiotic prophylaxis (PAP) is clearly indicated for operations that carry a high risk of SSI (e.g., colorectal surgery) and for those that involve the implantation of alloplastic material (e.g., hip endoprostheses). PAP can usually be administered with basic antibiotics such as cefazoline. The basic principles of PAP are that it should be given by the anesthesia team in the interval from 60 minutes preoperatively up to shortly before the incision, and that its administration should only be for a short period of time, usually as a single shot. Continuing PAP onward into the postoperative period leads to increased toxicity, bacterial superinfections, and antibiotic resistance.
conclusionThe evidence shows that perioperative antibiotic prophylaxis is a component of a bundle of measures that can help prevent SSI. Strict indications and adherence to the basic principles of PAP are essential for therapeutic success.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.