Evidence map›Paper›PMID 38440926›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2024

Acoustic Activation Imaging With Intravenous Perfluoropropane Nanodroplets Results in Selective Bioactivation of the Risk Area.

Shouqiang Li, Cheng Chen, John Lof, Elizabeth A Stolze, Jiri Sklenar, Xucai Chen, John J Pacella, Flordeliza S Villanueva, Terry O Matsunaga, E Carr Everbach and 6 more

Abstract read
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In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shouqiang LiDepartment of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Cheng ChenCenter for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John LofDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Elizabeth A StolzeDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Jiri Sklenarnarnar.co, Lake Oswego, Oregon, USA.
Xucai ChenCenter for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John J PacellaCenter for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Flordeliza S VillanuevaCenter for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Terry O MatsunagaDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona, USA.
E Carr EverbachDepartment of Engineering, Swarthmore College, Swarthmore, Pennsylvania, USA.
Stanley J RadioDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Sherry N WestphalDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Sruti ShivaDepartment of Pharmacology and Chemical Biology, Molecular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Feng XieDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Xiaoping LengDepartment of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Thomas R PorterDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0003-0881-946X

Funding

Scar Detection and Treatment with Droplet ActivationR01HL146489 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PORTER, THOMAS R · 2020 to 2023
$3.0M
NHLBI NIH HHS R01 HL146489NIH HHS
6 · The paper itself

Abstract

backgroundAcoustically activatable perfluoropropane droplets (PD) can be formulated from commercially available microbubble preparations. Diagnostic transthoracic ultrasound frequencies have resulted in acoustic activation (AA) predominately within myocardial infarct zones (IZ).

objectiveWe hypothesized that the AA area following acute coronary ischemia/reperfusion (I/R) would selectively enhance the developing scar zone, and target bioeffects specifically to this region.

methodsWe administered intravenous PD in 36 rats and 20 pigs at various stages of myocardial scar formation (30 minutes, 1 day, and 7 days post I/R) to determine what effect infarct age had on the AA within the IZ. This was correlated with histology, myeloperoxidase activity, and tissue nitrite activity.

resultsThe degree of AA within the IZ in rats was not associated with collagen content, neutrophil infiltration, or infarct age. AA within 24 hours of I/R was associated with increased nitric oxide utilization selectively within the IZ (P < .05 compared with remote zone). The spatial extent of AA in pigs correlated with infarct size only when performed before sacrifice at 7 days (r = .74, P < .01).

conclusionsAcoustic activation of intravenous PD enhances the developing scar zone following I/R, and results in selective tissue nitric oxide utilization.

Indexed as

FluorocarbonsMyocardial InfarctionAnimalsContrast MediaDisease Models, AnimalFemaleMaleMicrobubblesMyocardial Reperfusion InjuryMyocardiumNanoparticlesRatsRats, Sprague-DawleySwineUltrasonographyContrast MediaFluorocarbonsperflutrenacoustic activationdropletsimagingmyocardial ischemiaperfluoropropanereperfusion

Identifiers

PMID38440926
PMCPMC11093707

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.