ArticleCell reports2024
Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-R
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In one paragraph
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- The CALERIE Genomic Data Resource.Nature aging · 2025Trial
- Dietary restriction in aging and longevity.Nature aging · 2026Review
- PAI-1 is a common driver of aging and diverse diseases.Biomedical journal · 2026Review
- Biological Mechanisms of Strength Preservation During Calorie Restriction-Induced Weight Loss Among Young- to Middle-Aged Adults without Obesity.bioRxiv : the preprint server for biology · 2026Article
- Metabolic regulation in adult and aging skeletal muscle stem cells.Genes & development · 2025Review
- Role of plasminogen activator inhibitor-1 (PAI-1) in age-related cardiovascular pathophysiology.The journal of cardiovascular aging · 2025Article
- The CALERIEbioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 9 institutions in 1 country.
Akshay BarejaDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
David E LeeDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
Tricia HoProteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, NC, USA.
Greg WaittProteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, NC, USA.
Lauren H McKayDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of Chapel Hill, Chapel Hill, NC, USA.
Sarah A HannouDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
Melissa C OrenduffDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
Kristen M McGreevyDepartment of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA 90095, USA.
Alexandra BinderPopulation Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA 90095, USA.
Calen P RyanColumbia University Mailman School of Public Health, New York, NY, USA.
Erik J SoderblomProteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, NC, USA.
Daniel W BelskyColumbia University Mailman School of Public Health, New York, NY, USA.
Luigi FerrucciDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jayanta Kumar DasDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Nirad BanskotaLongitudinal Studies Section, Translation Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Virginia B KrausDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA.
Janet L HuebnerDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
William E KrausDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA.
Kim M HuffmanDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA.
Gurpreet S BahtDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA; Department of Orthopedic Surgery, Duke University School of Medicine, Durham, NC 27701, USA.
Steve HorvathComputational Biology and Genomics Core, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA; Altos Labs, San Diego, CA, USA.
Robert J ParmerDepartment of Medicine, Veterans Administration San Diego Healthcare System, San Diego, CA, USA; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Lindsey A MilesDepartment of Molecular Medicine, Scripps Research, La Jolla, CA 92037, USA.
James P WhiteDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA. Electronic address: james.white@duke.edu.
Duke University · USColumbia University · USNational Institutes of Health · USUniversity of California, Los Angeles · USScripps Institution of Oceanography · USUCLA Health · USUniversity of California San Diego · USUniversity of Hawaiʻi at Mānoa · USUniversity of North Carolina at Chapel Hill · US
Funding
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI CATHLEEN S COLON-EMERIC, Susan Nicole Hastings · 2006 to 2026
$24.6MTRANSFUSION MEDICINE AND RELATED AREAST32HL007057 · NHLBI · DUKE UNIVERSITY · PI Gowthami M Arepally · 1985 to 2026
$10.6MRegulation of plasminogen-dependent cell functions by the novel receptor, Plg-RKTR01HL081046 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI MILES, LINDSEY A · 2007 to 2024
$8.7MENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGYR33AG070455 · NIA · DUKE UNIVERSITY · PI KIM M. HUFFMAN, WILLIAM E KRAUS · 2021 to 2026
$4.0MA Novel Plasminogen Receptor Promotes Adipose Function and Metabolic HomeostasisR01HL149511 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI MILES, LINDSEY A, PARMER, ROBERT J · 2019 to 2022
$3.0MLong-term multi-omics follow-up of the CALERIE Trial to generate new knowledge for geroscienceR01AG061378 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Daniel Walker Belsky · 2019 to 2026
$2.9MA novel target in aged fracture healingR01AG081393 · NIA · DUKE UNIVERSITY · PI Gurpreet Baht · 2023 to 2026
$1.7MThe AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cellsK01AG056664 · NIA · DUKE UNIVERSITY · PI WHITE, JAMES P. · 2017 to 2022
$913kCorrection of Immune Response Improves Aged Fracture HealingR21AG067245 · NIA · DUKE UNIVERSITY · PI BAHT, GURPREET · 2020 to 2021
$443kAssessing healthspan and epigenetics in aged mice after prolonged exposure to young circulationR21AG065943 · NIA · DUKE UNIVERSITY · PI WHITE, JAMES P. · 2020 to 2021
$443kRegulation of Renal Injury and Fibrosis by the Plasminogen Receptor, Plg-RKTI01BX003933 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI PARMER, ROBERT J · 2018 to 2021
–BLRD VA I01 BX003933NHLBI NIH HHS R01 HL081046NHLBI NIH HHS R01 HL149511NHLBI NIH HHS T32 HL007057NIA NIH HHS K01 AG056664NIA NIH HHS P30 AG028716NIA NIH HHS R01 AG061378NIA NIH HHS R01 AG081393NIA NIH HHS R21 AG065943NIA NIH HHS R21 AG067245NIA NIH HHS R33 AG070455
Abstract
An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilized the MetRS
Indexed as
PlasminogenReceptors, Cell SurfaceAnimalsCaloric RestrictionCell ProliferationHumansLiverMiceMice, TransgenicMusclesSerine ProteasesPlasminogenReceptors, Cell SurfaceSerine ProteasesCALERIEcaloric restrictionCP: MetabolismCP: Stem cell researchliverMetRSmusclePAI-1plasminogensatellite cellsecretomestem cell
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.