Evidence map›Paper›PMID 38445671›Full record

ArticleMolecular metabolism2023

The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo.

Miguel Hernández-Quiles, Laura Martinez Campesino, Imogen Morris, Zabran Ilyas, Steve Reynolds, Nguan Soon Tan, Paula Sobrevals Alcaraz, Edwin C A Stigter, Ákos Varga, János Varga and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Miguel Hernández-QuilesCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3C584 CG Utrecht, The Netherlands.
Laura Martinez CampesinoDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2TN, UK.
Imogen MorrisCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3C584 CG Utrecht, The Netherlands.
Zabran IlyasDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2TN, UK.
Steve ReynoldsDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2TN, UK.
Nguan Soon TanLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, 11 Mandalay Road, 308232 Singapore, Singapore; School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, 637551 Singapore, Singapore.
Paula Sobrevals AlcarazOncode Institute and Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3C584 CG Utrecht, The Netherlands.
Edwin C A StigterCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3C584 CG Utrecht, The Netherlands.
Ákos VargaDepartment of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary.
János VargaDepartment of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary.
Robert van EsOncode Institute and Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3C584 CG Utrecht, The Netherlands.
Harmjan VosOncode Institute and Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3C584 CG Utrecht, The Netherlands.
Heather L WilsonDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2TN, UK.
Endre Kiss-TothDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2TN, UK.
Eric KalkhovenCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3C584 CG Utrecht, The Netherlands. Electronic address: e.kalkhoven@umcutrecht.nl.
Utrecht University · NLUniversity of Sheffield · GBUniversity of Szeged · HUNanyang Technological University · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn vivo studies in humans and mice have implicated the pseudokinase Tribbles 3 (TRIB3) in various aspects of energy metabolism. Whilst cell-based studies indicate a role for TRIB3 in adipocyte differentiation and function, it is unclear if and how these cellular functions may contribute to overall metabolic health.

methodsWe investigated the metabolic phenotype of whole-body Trib3 knockout (Trib3

resultsTrib3

conclusionsOur findings support TRIB3 playing multiple distinct regulatory roles in the cytoplasm, nucleus and mitochondria, ultimately controlling adipose tissue homeostasis, rather than affecting a single cellular pathway.

Indexed as

AdipocytesAdipose TissueProtein Serine-Threonine KinasesAnimalsCell Cycle ProteinsCell ProliferationHomeostasisHumansLipidsMiceRepressor ProteinsCell Cycle ProteinsLipidsProtein Serine-Threonine KinasesRepressor ProteinsTRB3 protein, mouseTRIB3 protein, humanAdipocyteMetabolismOmics analysesTribbles

Identifiers

PMID38445671
PMCPMC10663684
OpenAlexW4388096660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.