Evidence map›Paper›PMID 38445691›Full record

SynthesisInfectious disorders drug targets2024

Comparison of Omicron and Delta Variants of SARS-CoV-2: A Systematic Review of Current Evidence.

SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Pegah Mirzapour, Arian Afzalian, Ramin Shahidi, Mohsen Dashti, Afsaneh Ghasemzadeh, Parinaz Paranjkhoo, Zahra Parsaei, Ava Pashaei and 9 more

Abstract readSystematic ReviewComparative Study
PubMed Publisher
In one paragraph

Synthesis in Infectious disorders drug targets, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

SeyedAhmad SeyedAlinaghiIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Amir Masoud AfsahiDepartment of Radiology, School of Medicine, University of California, San Diego (UCSD), California, USA.
Pegah MirzapourIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Arian AfzalianSchool of medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ramin ShahidiSchool of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Mohsen DashtiDepartment of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran.
Afsaneh GhasemzadehDepartment of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran.
Parinaz ParanjkhooTurpanjian College of Health Sciences, American University of Armenia, Yerevan, 0019, Armenia.
Zahra ParsaeiHealth Information Technology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Ava PashaeiSchool of Nursing, University of British Columbia, Vancouver, British Columbia, Canada.
Parsa MohammadiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Sadeq NajafiResearch Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Sona MahrokhiIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Parisa MatiniSchool of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Ali MoradiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Amirali KarimiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Solaiman AfroughiDepartment of Biostatistics and Epidemiology, School of Health and Social Determinants of Health Research Center, Postal Code 7591875114, Yasuj University of Medical Sciences, Yasuj, Iran.
Esmaeil MehraeenDepartment of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran.
Omid DadrasDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, 5007, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSevere acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) caused the outbreak of coronavirus disease 2019 (COVID-19) in late 2019 in Wuhan, China. In early 2020, the disease spread rapidly around the world. Since the pandemic, SARS-CoV-2 has evolved dramatically into a wide variety of variants endowed with devastating properties. As of March 6, 2022, five SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, Delta, and Omicron strains have been identified. Due to the crucial importance of understanding the differences between the Omicron and Delta variants, this systematic review was conducted.

methodsThis systematic review investigated new variants of Omicron SARS-CoV-2 based on current studies. Online databases were searched for English articles as of January 03, 2023. Selection of publications was a two-step process of title/abstract and full-text assessment against eligibility criteria. The relevant data from the included articles were systematically collected and organized in a designed table for analysis. To ensure the quality of the review, the PRISMA checklist and Newcastle- Ottawa Scale (NOS) of quality assessment were utilized.

resultsThe data extracted from 58 articles were analyzed, including 10003 pieces of evidence. Lower risk of hospitalization, ICU admission, and mortality after vaccination were reported in the Omicron variant compared to the Delta variant. Additionally, the Delta variant led to more severe clinical symptoms in comparison to the Omicron variant.

conclusionThe Omicron variant of SARS-CoV-2 results in less severe disease outcomes as compared to Delta. Nevertheless, it remains crucial to maintain ongoing monitoring, implement containment measures, and adapt vaccination protocols to effectively address the evolving variants.

Indexed as

COVID-19SARS-CoV-2COVID-19 VaccinesHumansCOVID-19 VaccinesCoronavirus disease 2019COVID-19Delta variantOmicron new variant.Omicron subvariantSARS-CoV-2

Identifiers

PMID38445691

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.