Evidence map›Paper›PMID 38445950›Full record

Trial reportCirculation. Heart failure2024

Impact of Rapid Up-Titration of Guideline-Directed Medical Therapies on Quality of Life: Insights From the STRONG-HF Trial.

Jelena Čelutkienė, Kamilė Čerlinskaitė-Bajorė, Gad Cotter, Christopher Edwards, Marianna Adamo, Mattia Arrigo, Marianela Barros, Jan Biegus, Ovidiu Chioncel, Alain Cohen-Solal and 20 more

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Circulation. Heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07547878 phase4not yet recruitingstarted 2026, after this paper: background citation

A Pilot Randomized Clinical Trial to Assess Feasibility, Safety, and Efficacy of Rapid, Simultaneous Therapy Initiation in Chronic Kidney Disease and Type 2 Diabetes: RAPID-CKD

Ran2026Enrolled64Registered outcomes18Posted comparisons0ConditionsChronic Kidney Disease, Type 2 DiabetesArmsAccupril, Aceon, Altace, Atacand, Avapro
PMID 34423370PMID 38785209PMID 37952217PMID 34529313PMID 34655282PMID 34779091PMID 34950508PMID 35072048PMID 26264780PMID 35529086PMID 35935070PMID 36148880other papers from this trial
Open the trial in the graph
NCT03412201 naunknown statusnot on this map

Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP testinG, of Heart Failure Therapies

TypeinterventionalSponsorHeart InitiativeRan2018 to 2021Enrolled1,800ConditionsHeart FailureArmsUsual Care, High Intensity Care
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Review
  7. 2024 update in heart failure.ESC heart failure · 2025
    Review
  8. High-intensity care for GDMT titration.Heart failure reviews · 2024
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 14 institutions in 13 countries.

Jelena ČelutkienėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Lithuania (J.Č., K.Č-B.).ORCID 0000-0003-3562-9274
Kamilė Čerlinskaitė-BajorėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Lithuania (J.Č., K.Č-B.).ORCID 0000-0002-6753-9356
Gad CotterUniversité Paris Cité, INSERM UMR-S 942 (MASCOT), France (G.C., A.C.-S., E.G., V.L., A.M., B.D.).
Christopher EdwardsMomentum Research, Inc, Durham, NC. (G.C., C.E., M.B., M.N., K.T., B.D.).ORCID 0000-0003-4908-9758
Marianna AdamoCardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M. Adamo, M.M., M.P., D.T.).ORCID 0000-0002-3855-1815
Mattia ArrigoDepartment of Internal Medicine, Stadtspital Zurich, Switzerland (M. Arrigo).ORCID 0000-0003-4028-2869
Marianela BarrosMomentum Research, Inc, Durham, NC. (G.C., C.E., M.B., M.N., K.T., B.D.).
Jan BiegusInstitute of Heart Diseases, Wroclaw Medical University, Poland (J.B., P.P.).ORCID 0000-0001-9977-7722
Ovidiu ChioncelEmergency Institute for Cardiovascular Diseases "Prof. C.C.Iliescu," University of Medicine "Carol Davila," Bucharest, Romania (O.C.).ORCID 0000-0002-3197-3628
Alain Cohen-SolalClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Lithuania (J.Č., K.Č-B.).
Albertino DamascenoFaculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique (A.D.).ORCID 0000-0003-0925-494X
Rafael DiazEstudios Clínicos Latinoamérica, Instituto Cardiovascular de Rosario, Argentina (R.D.).ORCID 0000-0003-2181-9579
Gerasimos FilippatosNational and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Greece (G.F.).ORCID 0000-0002-5640-0332
Etienne GayatClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Lithuania (J.Č., K.Č-B.).ORCID 0000-0002-3334-3849
Antoine KimmounUniversité de Lorraine, Nancy; INSERM, Défaillance Circulatoire Aigue et Chronique; Service de Médecine Intensive et Réanimation Brabois, CHRU de Nancy, France (A.K.).ORCID 0000-0002-5443-2074
Valentine LéopoldClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Lithuania (J.Č., K.Č-B.).ORCID 0000-0002-2131-5760
Marco MetraCardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M. Adamo, M.M., M.P., D.T.).ORCID 0000-0003-4846-8529
Maria NovosadovaMomentum Research, Inc, Durham, NC. (G.C., C.E., M.B., M.N., K.T., B.D.).
Matteo PagnesiCardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M. Adamo, M.M., M.P., D.T.).ORCID 0000-0002-9298-7871
Peter S PangDepartments of Emergency Medicine and Medicine, Indiana University School of Medicine, Indianapolis (P.S.P.).ORCID 0000-0003-3444-2811
Piotr PonikowskiInstitute of Heart Diseases, Wroclaw Medical University, Poland (J.B., P.P.).ORCID 0000-0002-3391-7064
Hadiza SaiduMurtala Muhammed Specialist Hospital/Bayero University Kano, Nigeria (H.S.).
Karen SliwaCape Heart Institute, Division of Cardiology, Department of Medicine, Groote Schuur Hospital and University of Cape Town, South Africa (K.S.).ORCID 0000-0002-8272-0911
Koji TakagiMomentum Research, Inc, Durham, NC. (G.C., C.E., M.B., M.N., K.T., B.D.).
Jozine M Ter MaatenDepartment of Cardiology, Medical Centre Groningen, the Netherlands (J.M.T.M., A.A.V.).
Daniela TomasoniCardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M. Adamo, M.M., M.P., D.T.).ORCID 0000-0002-7584-2857
Carolyn S P LamNational Heart Centre Singapore and Duke-National University of Singapore, Singapore (C.S.P.L.).ORCID 0000-0002-5417-4415
Adriaan A VoorsDepartment of Cardiology, Medical Centre Groningen, the Netherlands (J.M.T.M., A.A.V.).ORCID 0000-0002-5417-4415
Alexandre MebazaaClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Lithuania (J.Č., K.Č-B.).ORCID 0000-0001-8715-7753
Beth DavisonClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Lithuania (J.Č., K.Č-B.).ORCID 0000-0003-2374-6449
Vilnius University · LTMomentum Research · USSurgical Specialties (United States) · USUniversity Medical Center Groningen · NLInserm · FRWroclaw Medical University · PLBayero University Kano · NGCarol Davila University of Medicine and Pharmacy · ROEduardo Mondlane University · MZEstudios Clínicos Latinoamérica · ARGroote Schuur Hospital · ZAIndiana University – Purdue University Indianapolis · USNational and Kapodistrian University of Athens · GRStadtspital Waid · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis analysis provides details on baseline and changes in quality of life (QoL) and its components as measured by EQ-5D-5L questionnaire, as well as association with objective outcomes, applying high-intensity heart failure (HF) care in patients with acute HF.

methodsIn STRONG-HF trial (Safety, Tolerability, and Efficacy of Rapid Optimization, Helped by NT-proBNP Testing, of Heart Failure Therapies) patients with acute HF were randomized just before discharge to either usual care or a high-intensity care strategy of guideline-directed medical therapy up-titration. Patients ranked their state of health on the EQ-5D visual analog scale score ranging from 0 (the worst imaginable health) to 100 (the best imaginable health) at baseline and at 90 days follow-up.

resultsIn 1072 patients with acute HF with available assessment of QoL (539/533 patients assigned high-intensity care/usual care) the mean baseline EQ-visual analog scale score was 59.2 (SD, 15.1) with no difference between the treatment groups. Patients with lower baseline EQ-visual analog scale (meaning worse QoL) were more likely to be women, self-reported Black and non-European (

conclusionsEarly up-titration of guideline-directed medical therapy significantly improves all dimensions of QoL in patients with HF and improves prognosis regardless of baseline self-assessed health status. The likelihood of achieving optimal doses of HF medications does not depend on baseline QoL. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03412201.

Indexed as

Heart FailureBiomarkersFemaleHumansMaleNatriuretic Peptide, BrainPeptide FragmentsQuality of LifeStroke VolumeVentricular Function, LeftBiomarkersNatriuretic Peptide, BrainPeptide Fragmentsatrial fibrillationblood pressuredepressionheart failurequality of life

Identifiers

PMID38445950
OpenAlexW4392506577

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.