Evidence map›Paper›PMID 38446387›Full record

ArticleEndocrine2024

Nicotinamide protects against diabetic kidney disease through regulation of Sirt1.

Yeping Yang, Jinya Huang, Lijie Xie, Yilin Wang, Shizhe Guo, Meng Wang, Xiaoqing Shao, Wenjuan Liu, Yi Wang, Qin Li and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yeping YangDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jinya HuangDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Lijie XieDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yilin WangDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Shizhe GuoDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Meng WangDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiaoqing ShaoDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Wenjuan LiuDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yi WangDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Qin LiDivision of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China.
Xia WuDepartment of Endocrinology and Metabolism, Jing'an District Center Hospital of Shanghai, Shanghai, 200040, China.
Zhaoyun ZhangDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Fangfang ZengDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China. zengfangfang@huashan.org.cn.
Wei GongDivision of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China. nj_gongwei2001@sina.cn.ORCID 0009-0003-3813-256X
Fudan University · CNHuashan Hospital · CNShanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China 82170841Shanghai Pujiang Program 20PJ1402100
6 · The paper itself

Abstract

purposeTo investigate the effect of nicotinamide (Nam) on diabetic kidney disease (DKD) in mice and explore its mechanism.

methodsThirty DBA/2 J mice were randomly assigned to three groups. After 8 weeks of hyperglycemia induced by streptozocin (STZ), Nam and saline were administrated to STZ + Nam and STZ + NS mice, respectively, for 8 weeks. Non-diabetic mice (NDM) were used as control group. Twenty In2

resultsUrinary albumin-to-creatinine ratio (UACR) and kidney injury molecule 1 (KIM-1) decreased in the STZ + Nam and Akita + Nam groups. Pathological analysis showed that Nam improved the structure of glomerular basement membrane, ameliorated glomerular sclerosis, and decreased the accumulation of extracellular matrix and collagen. Compared to the diabetic control group, renal fibrosis, inflammation, and oxidative stress were reduced in the Nam-treated mice. The expression of sirtuin 1 (Sirt1) in human proximal tubular HK2 cells was inhibited by high glucose and Nam treatment enhanced its expression. However, in HK2 cells with Sirt1 knockdown, the protective effect of Nam was abolished, indicating that the beneficial effect of Nam was partially dependent on Sirt1.

conclusionsNam has a renoprotective effect against renal injury caused by hyperglycemia and may be a potential target for the treatment of DKD.

Indexed as

Diabetes Mellitus, ExperimentalDiabetic NephropathiesMice, Inbred DBANiacinamideSirtuin 1AnimalsCell LineHumansKidneyMaleMiceOxidative StressVitamin B ComplexNiacinamideSirt1 protein, mouseSirtuin 1Vitamin B ComplexDiabetic kidney diseaseFibrosisNicotinamideOxidative stressProximal tubuleSirtuin 1

Identifiers

PMID38446387
PMCPMC11291543
OpenAlexW4392499101

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.