Evidence map›Paper›PMID 38449452›Full record

ArticleThe world journal of men's health2024

Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men.

Geoffrey Hackett, Amar Mann, Ahmad Haider, Karim S Haider, Pieter Desnerck, Carola S König, Richard C Strange, Sudarshan Ramachandran

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The world journal of men's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Geoffrey HackettSchool of Biosciences, College of Health and Life Sciences, Aston University, Birmingham, UK.ORCID https://orcid.org/0000-0003-2073-3001
Amar MannDepartment of Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust, West Midlands, UK.ORCID https://orcid.org/0000-0002-7972-4794
Ahmad HaiderUrological Practice Dr Haider, Bremerhaven, Germany.ORCID https://orcid.org/0000-0001-9252-0588
Karim S HaiderUrological Practice Dr Haider, Bremerhaven, Germany.ORCID https://orcid.org/0000-0003-4396-9324
Pieter DesnerckDepartment of Engineering, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-8042-9741
Carola S KönigDepartment of Mechanical and Aerospace Engineering, Brunel University London, London, UK.ORCID https://orcid.org/0000-0002-9289-3154
Richard C StrangeSchool of Pharmacy and Bioengineering, Keele University, Staffordshire, UK.ORCID https://orcid.org/0000-0002-0980-6348
Sudarshan RamachandranDepartment of Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust, West Midlands, UK.ORCID https://orcid.org/0000-0003-2299-4133
University Hospitals Birmingham NHS Foundation Trust · GBAston University · GBBrunel University of London · GBKeele University · GBUniversity of Cambridge · GB

Funding

North Staffordshire Medical Institute PID-200078
6 · The paper itself

Abstract

purposeWhile testosterone therapy can improve the various pathologies associated with adult-onset testosterone deficiency (TD), Summary of Product Characteristics (SPC) of five testosterone preparations caution that treatment may be associated with hypertension. This paper evaluates the impact of testosterone undecanoate (TU) on blood pressure (BP) in men with adult-onset TD. MATERIALS AND

methodsOf 737 men with adult-onset TD in an on-going, observational, prospective, cumulative registry, we studied changes in BP using non-parametric sign-rank tests at final assessment and fixed time points. We used multiple regression analysis to establish factors (baseline BP, age, change/baseline waist circumference [WC] and hematocrit [HCT] and follow-up) potentially associated with BP change in men on TU.

resultsTU was associated with significant reductions in systolic, diastolic BP and pulse pressure, regardless of antihypertensive therapy (at baseline or during follow-up), larger reductions were seen with concurrent antihypertensive therapy. In men never on antihypertensive agents, median changes (interquartile range [IQR]) in systolic BP, diastolic BP and pulse pressure were -12.5 (-19.0, -8.0), -8.0 (-14.0, -3.0), and -6.0 (-10.0, -1.0) mmHg, respectively at final assessment, with only baseline BP values inversely associated with these changes (HCT and WC were not significantly associated). In men not on TU, systolic BP, diastolic BP, and pulse pressure significantly increased. In the TU treated men only 1 of the 152 men (not on antihypertensive agents at baseline) were started on antihypertensives during follow-up. In contrast 33 of the 202 men on antihypertensives (at baseline or follow-up) had the antihypertensive agent discontinued by the end of the follow-up.

conclusionsTU was associated with lowering of BP during follow-up irrespective of antihypertensive therapy, with greater reductions in men with higher baseline BP. In the context of SPC warnings, our long-term data provide reassurance on the effect of TU on BP.

Indexed as

Blood pressureHematocritHypogonadismTestosteroneWaist circumference

Identifiers

PMID38449452
PMCPMC11439806
OpenAlexW4392833022

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.