Evidence map›Paper›PMID 38449737›Full record

ArticleFrontiers in neuroscience2024

EZH2 inhibition reactivates epigenetically silenced

Minggang Fang, Sara K Deibler, Pranathi Meda Krishnamurthy, Feng Wang, Paola Rodriguez, Shahid Banday, Ching-Man Virbasius, Miguel Sena-Esteves, Jonathan K Watts, Michael R Green

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Minggang FangDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Sara K DeiblerDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Pranathi Meda KrishnamurthyRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Feng WangRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Paola RodriguezDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Shahid BandayDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Ching-Man VirbasiusDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Miguel Sena-EstevesDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Jonathan K WattsRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Michael R GreenDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
University of Massachusetts Chan Medical School · US

Funding

Next-generation antisense therapeutics for ALS and frontotemporal dementiaR01NS111990 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Robert H Brown, Jonathan K Watts · 2019 to 2026
$5.2M
Reactivation of Epigenetically Silenced FMR1 as a Therapeutic Approach for Fragile X SyndromeR01MH113874 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GREEN, MICHAEL R · 2017 to 2021
$2.1M
NIMH NIH HHS R01 MH113874NINDS NIH HHS R01 NS111990
6 · The paper itself

Abstract

Fragile X Syndrome (FXS) is a neurological disorder caused by epigenetic silencing of the

Indexed as

ASO - antisense oligonucleotidesEZH2 (enhancer of zeste homolog 2)FMR1 reactivationFMR1 silencingFXSneuron differentiation

Identifiers

PMID38449737
PMCPMC10915284
OpenAlexW4392002047

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.