Evidence map›Paper›PMID 38451091›Full record

ArticleMicrobiology spectrum2024

Ribosome profiling reveals downregulation of UMP biosynthesis as the major early response to phage infection.

Patrick B F O'Connor, Jennifer Mahony, Eoghan Casey, Pavel V Baranov, Douwe van Sinderen, Martina M Yordanova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Patrick B F O'ConnorSchool of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.
Jennifer MahonySchool of Microbiology and APC Microbiome Ireland, University College Cork, Cork, Ireland.
Eoghan CaseySchool of Microbiology and APC Microbiome Ireland, University College Cork, Cork, Ireland.
Pavel V BaranovSchool of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.
Douwe van SinderenSchool of Microbiology and APC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0003-1823-7957
Martina M YordanovaSchool of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.ORCID 0000-0001-9693-3857
University College Cork · IE

Funding

Wellcome TrustWellcome Trust 210692/Z/18
6 · The paper itself

Abstract

Bacteria have evolved diverse defense mechanisms to counter bacteriophage attacks. Genetic programs activated upon infection characterize phage-host molecular interactions and ultimately determine the outcome of the infection. In this study, we applied ribosome profiling to monitor protein synthesis during the early stages of sk1 bacteriophage infection in IMPORTANCE: The ribosome profiling technology has provided invaluable insights for understanding cellular translation and eukaryotic viral infections. However, its potential for investigating host-phage interactions remains largely untapped. Here, we applied ribosome profiling to

Indexed as

BacteriophagesLactococcusProtein BiosynthesisDown-RegulationNucleotidesRibosome ProfilingRNA, MessengerUridine MonophosphateNucleotidesRNA, MessengerUridine Monophosphateanti-phage responsemRNA translationribosome profiling

Identifiers

PMID38451091
PMCPMC10986495
OpenAlexW4392561641

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.