Evidence map›Paper›PMID 38452902›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2024

Sex-specific Stone-forming Phenotype in Mice During Hypercalciuria/Urine Alkalinization.

Eugenia Awuah Boadi, Samuel Shin, Bok-Eum Choi, Khanh Ly, Christopher B Raub, Bidhan C Bandyopadhyay

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Eugenia Awuah BoadiCalcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, Washington, DC.
Samuel ShinCalcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, Washington, DC; Department of Biomedical Engineering, The Catholic University of America, Washington DC.
Bok-Eum ChoiCalcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, Washington, DC.
Khanh LyDepartment of Biomedical Engineering, The Catholic University of America, Washington DC.
Christopher B RaubDepartment of Biomedical Engineering, The Catholic University of America, Washington DC.
Bidhan C BandyopadhyayCalcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, Washington, DC; Department of Biomedical Engineering, The Catholic University of America, Washington DC; Division of Renal Diseases and Hypertension, Department of Medicine, The George Washington University, Washington DC. Electronic address: bidhan.bandyopadhyay@va.gov.
Veterans Health Administration · USUniversity of America · USWashington University Medical Center · US

Funding

Calcium transport in kidney proximal tubule and calcium phosphate stone formationR01DK102043 · NIDDK · INSTITUTE FOR CLINICAL RESEARCH, INC. · PI BANDYOPADHYAY, BIDHAN CHANDRA · 2015 to 2019
$1.1M
NIDDK NIH HHS R01 DK102043
6 · The paper itself

Abstract

Sex differences in kidney stone formation are well known. Females generally have slightly acidic blood and higher urine pH when compared with males, which makes them more vulnerable to calcium stone formation, yet the mechanism is still unclear. We aimed to examine the role of sex in stone formation during hypercalciuria and urine alkalinization through acetazolamide and calcium gluconate supplementation, respectively, for 4 weeks in wild-type (WT) and moderately hypercalciuric [TRPC3 knockout [KO](-/-)] male and female mice. Our goal was to develop calcium phosphate (CaP) and CaP+ calcium oxalate mixed stones in our animal model to understand the underlying sex-based mechanism of calcium nephrolithiasis. Our results from the analyses of mice urine, serum, and kidney tissues show that female mice (WT and KO) produce more urinary CaP crystals, higher [Ca

Indexed as

HypercalciuriaKidney CalculiMice, KnockoutPhenotypeAnimalsCalcium OxalateCalcium PhosphatesDisease Models, AnimalFemaleHydrogen-Ion ConcentrationKidneyMaleMiceMice, Inbred C57BLSex CharacteristicsSex FactorsCalcium Oxalatecalcium phosphateCalcium PhosphatesTRPC3 cation channelTRPC Cation Channelscalcium nephrolithiasishypercalciuriaoxidative stressproximal tubular acidosissex differencesurinary stones

Identifiers

PMID38452902
PMCPMC11103239
OpenAlexW4392469634

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.