Evidence map›Paper›PMID 38453819›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2024

New thymol-derived triazole exhibits promising activity against Trichophyton rubrum.

Thiago Antonio de Sousa Cutrim, Mariana Alves Eloy, Fernando Fontes Barcelos, Leandra Martins Meireles, Lara Chaves de Freitas Ferreira, Tatiana Alves Reis, Sarah Santos Gonçalves, Valdemar Lacerda, Marcio Fronza, Pedro Alves Bezerra Morais and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thiago Antonio de Sousa CutrimPharmaceutical Sciences Graduate Program, Universidade Vila Velha, Comissário José Dantas de Melo St., 21, Boa Vista, Vila Velha, Espírito Santo, 29102-770, Brazil.
Mariana Alves EloyAgrochemical Graduate Program, Federal University of Espírito Santo, Alegre, Espirito Santo, 29500-000, Brazil.
Fernando Fontes BarcelosPlant Biotechnology Graduate Program, Universidade Vila Velha, Vila Velha, Espírito Santo, 29102-770, Brazil.
Leandra Martins MeirelesPharmaceutical Sciences Graduate Program, Universidade Vila Velha, Comissário José Dantas de Melo St., 21, Boa Vista, Vila Velha, Espírito Santo, 29102-770, Brazil.
Lara Chaves de Freitas FerreiraAgrochemical Graduate Program, Federal University of Espírito Santo, Alegre, Espirito Santo, 29500-000, Brazil.
Tatiana Alves ReisDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Sarah Santos GonçalvesCenter for Research in Medical Mycology, Department of Pathology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Valdemar LacerdaChemistry Graduate Program, Universidade Federal Do Espírito Santo, Vitória, Espírito Santo, Brazil.
Marcio FronzaPharmaceutical Sciences Graduate Program, Universidade Vila Velha, Comissário José Dantas de Melo St., 21, Boa Vista, Vila Velha, Espírito Santo, 29102-770, Brazil.
Pedro Alves Bezerra MoraisAgrochemical Graduate Program, Federal University of Espírito Santo, Alegre, Espirito Santo, 29500-000, Brazil. pedro.morais@ufes.br.
Rodrigo SchererPharmaceutical Sciences Graduate Program, Universidade Vila Velha, Comissário José Dantas de Melo St., 21, Boa Vista, Vila Velha, Espírito Santo, 29102-770, Brazil. rodrigo.scherer@uvv.br.ORCID http://orcid.org/0000-0001-7656-0248

Funding

Fundação de Amparo à Pesquisa e Inovação do Espírito Santo 728/2016
6 · The paper itself

Abstract

Fungal infections have emerged worldwide, and azole antifungals are widely used to control these infections. However, the emergence of antifungal resistance has been compromising the effectiveness of these drugs. Therefore, the objective of this study was to evaluate the antifungal and cytotoxic activities of the nine new 1,2,3 triazole compounds derived from thymol that were synthesized through Click chemistry. The binding mode prediction was carried out by docking studies using the crystallographic structure of Lanosterol 14α-demethylase G73E mutant from Saccharomyces cerevisiae. The new compounds showed potent antifungal activity against Trichophyton rubrum but did not show relevant action against Aspergillus fumigatus and Candida albicans. For T. rubrum, molecules nº 5 and 8 showed promising results, emphasizing nº 8, whose fungicidal and fungistatic effects were similar to fluconazole. In addition, molecule nº 8 showed low toxicity for keratinocytes and fibroblasts, concluding that this compound demonstrates promising characteristics for developing a new drug for dermatophytosis caused by T. rubrum, or serves as a structural basis for further research.

Indexed as

Antifungal AgentsArthrodermataceaeMicrobial Sensitivity TestsMolecular Docking SimulationThymolTriazolesAspergillus fumigatusCandida albicansHumansKeratinocytesSaccharomyces cerevisiaeTrichophytonAntifungal AgentsThymolTriazolesAspergillusCandidaThymolTriazoleTrichophyton rubrum

Identifiers

PMID38453819
PMCPMC11153403

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.