ArticleFluids and barriers of the CNS2024
Validating the accuracy of real-time phase-contrast MRI and quantifying the effects of free breathing on cerebrospinal fluid dynamics.
Article in Fluids and barriers of the CNS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 23 citations in OpenAlex.
- Flow 2.0: A Standardized Toolbox for Real-Time Phase-Contrast MRI of Neurofluid Dynamics.Magnetic resonance in medicine · 2026Article
- Quantifying Cardiac, Respiratory, and Low Frequency Components of CSF Motion From fMRI Inflow Effects.Magnetic resonance in medicine · 2026Article
- Relationships Between Lateral Ventricle Size, Cerebrospinal Fluid Dynamics, and Aqueductal Resistance in Young Healthy Adults.Journal of magnetic resonance imaging : JMRI · 2026Article
- Simultaneous Real-time Imaging of Neurofluid and Neurovascular Dynamics Using Ultrafast Flow-weighted Echo-Planar Imaging.bioRxiv : the preprint server for biology · 2026Article
- Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery.Frontiers in drug delivery · 2026Review
- Simultaneous real-time imaging of upper cervical cerebrospinal fluid and vascular dynamics using ultrafast inflow-weighted EPI.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Dynamic analysis of lumbar spine cerebrospinal fluid flow during deep respiration using a modified time-spatial labeling inversion pulse: technical feasibility in a healthy volunteer.Skeletal radiology · 2026Article
- Imaging blood to periarterial CSF flow coupling using 4D flow MRI and an ultra-high-performance head-only gradient system.Fluids and barriers of the CNS · 2025Article
- Quantitative evaluation of low-frequency oscillations using real-time phase-contrast MRI during drowsiness.Fluids and barriers of the CNS · 2025Article
- Synchronous quantification of arterial, venous, and cerebrospinal fluid flow dynamics using real-time phase-contrast MRI.Fluids and barriers of the CNS · 2025Article
- Decreased quantitative transport mapping velocity in the middle cerebral artery-supplied temporal lobe in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Interrater and intrarater reliability of aqueduct CSF flow parameters measured by phase-contrast MRI in healthy adults.Quantitative imaging in medicine and surgery · 2025Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults.Fluids and barriers of the CNS · 2025Article
- Quantitative evaluation of normal cerebrospinal fluid flow in Sylvian aqueduct and perivascular spaces of middle cerebral artery and circle of Willis using 2D phase-contrast MRI imaging.Frontiers in neuroscience · 2025Article
- Cerebrospinal fluid pressure dynamics as a biomechanical marker for quantification of spinal cord compression: Conceptual framework and systematic review of clinical trials.Brain & spine · 2025Review
- BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI.Fluids and barriers of the CNS · 2024Article
- Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate.Brain multiphysics · 2024Article
- Phase-contrast MRI analysis of cerebral blood and CSF flow dynamic interactions.Fluids and barriers of the CNS · 2024Article
- Significant individual variation in cardiac-cycle-linked cerebrospinal fluid production following subarachnoid hemorrhage.Fluids and barriers of the CNS · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundUnderstanding of the cerebrospinal fluid (CSF) circulation is essential for physiological studies and clinical diagnosis. Real-time phase contrast sequences (RT-PC) can quantify beat-to-beat CSF flow signals. However, the detailed effects of free-breathing on CSF parameters are not fully understood. This study aims to validate RT-PC's accuracy by comparing it with the conventional phase-contrast sequence (CINE-PC) and quantify the effect of free-breathing on CSF parameters at the intracranial and extracranial levels using a time-domain multiparametric analysis method.
methodsThirty-six healthy participants underwent MRI in a 3T scanner for CSF oscillations quantification at the cervical spine (C2-C3) and Sylvian aqueduct, using CINE-PC and RT-PC. CINE-PC uses 32 velocity maps to represent dynamic CSF flow over an average cardiac cycle, while RT-PC continuously quantifies CSF flow over 45-seconds. Free-breathing signals were recorded from 25 participants. RT-PC signal was segmented into independent cardiac cycle flow curves (Q
resultsRT-PC overestimated CSF area (82.7% at aqueduct, 11.5% at C2-C3) compared to CINE-PC. Stroke volumes for CINE-PC were 615 mm³ (aqueduct) and 43 mm³ (spinal), and 581 mm³ (aqueduct) and 46 mm³ (spinal) for RT-PC. During thoracic pressure increase, spinal CSF net flow, flow amplitude, SV, and cardiac period increased by 6.3%, 6.8%, 14%, and 6%, respectively. Breathing effects on net flow showed a significant phase difference compared to the other parameters. Aqueduct-CSF flows were more affected by breathing than spinal-CSF.
conclusionsRT-PC accurately quantifies CSF oscillations in real-time and eliminates the need for cardiac synchronization, enabling the quantification of the cardiac and breathing components of CSF flow. This study quantifies the impact of free-breathing on CSF parameters, offering valuable physiological references for understanding the effects of breathing on CSF dynamics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.