Evidence map›Paper›PMID 38456483›Full record

Trial reportSubstance use & addiction journal2024

Perception and Correlates of Opioid Overdose Risk Among Overdose Survivors Who Use Nonprescribed Opioids in San Francisco and Boston.

Yi-Shin Grace Chang, Vanessa M McMahan, Xochitl Luna Marti, Emily Pope, Shae Wolfe, Adam Majeski, Gabriela Reed, Alexander Y Walley, Phillip O Coffin

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Substance use & addiction journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi-Shin Grace ChangCenter on Substance Use and Health, San Francisco Department of Public Health, San Francisco, CA, USA.ORCID 0009-0008-3163-0343
Vanessa M McMahanCenter on Substance Use and Health, San Francisco Department of Public Health, San Francisco, CA, USA.
Xochitl Luna MartiCenter on Substance Use and Health, San Francisco Department of Public Health, San Francisco, CA, USA.
Emily PopeCenter on Substance Use and Health, San Francisco Department of Public Health, San Francisco, CA, USA.
Shae WolfeGrayken Center for Addiction and Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.ORCID 0009-0003-1299-2692
Adam MajeskiGrayken Center for Addiction and Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.
Gabriela ReedGrayken Center for Addiction and Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.
Alexander Y WalleyGrayken Center for Addiction and Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.
Phillip O CoffinCenter on Substance Use and Health, San Francisco Department of Public Health, San Francisco, CA, USA.

Funding

Repeated-dose behavioral intervention to reduce opioid overdose: a two-site randomized-controlled efficacy trialR01DA045690 · NIDA · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI COFFIN, PHILLIP O · 2018 to 2022
$4.0M
Mentoring the next generation of addiction clinician scientists while responding to the opioid epidemicR25DA037756 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI FAIRBAIRN, NADIA · 2014 to 2023
$3.6M
Midcareer K24 Award for Mentoring and Patient-Oriented ResearchK24DA042720 · NIDA · SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH · PI PHILLIP O COFFIN · 2016 to 2026
$1.6M
NIDA NIH HHS K24 DA042720NIDA NIH HHS R01 DA045690NIDA NIH HHS R25 DA037756
6 · The paper itself

Abstract

backgroundUnderstanding opioid overdose risk perception may inform overdose prevention strategies.

methodsWe used baseline data from a randomized overdose prevention trial, in San Francisco, CA, and Boston, MA, among people who used nonprescribed opioids, survived an overdose in the past 3 years, and had received naloxone. Participants were asked how likely they were to overdose in the next 4 months. We combined "extremely likely" and "likely" (higher risk perception) and "neutral," "unlikely," and "extremely unlikely" (lower risk perception). We performed bivariate analyses and separate multivariable logistic regression models of risk perception across (1) sociodemographic, (2) substance use, and (3) overdose risk behavior measures. Covariates were selected

resultsAmong 268 participants, 88% reported at least 1 overdose risk behavior; however, only 21% reported higher risk perception. The adjusted odds ratio (AOR) of higher risk perception was 2.41 (95% confidence interval [CI]: 1.10-5.30) among those unhoused in the past 4 months, 2.06 (95% CI: 1.05-4.05) among those using opioids in a new place, and 5.61 (95% CI: 2.82-11.16) among those who had overdosed in the past 4 months. Living in Boston was associated with higher risk perception in all 3 models (AOR = 2.00-2.46, 95% CI: 1.04-4.88).

conclusionsDespite prevalent risk behaviors, a minority of participants perceived themselves to be at higher risk of overdose. Nonetheless, some known risk factors for overdose were appropriately associated with risk perception. Fentanyl has been prevalent in Boston for longer than San Francisco, which may explain the higher risk perception there.

Indexed as

Analgesics, OpioidOpiate OverdoseAdultBostonDrug OverdoseFemaleHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPerceptionRisk FactorsRisk-TakingSan FranciscoAnalgesics, OpioidNaloxoneNarcotic Antagonistsfentanylheroinopioid overdoserisk perception

Identifiers

PMID38456483
PMCPMC11588015

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.