Evidence map›Paper›PMID 38456502›Full record

ArticleJCI insight2024

CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification.

Yan Zhao, Yang Yang, Xiuju Wu, Li Zhang, Xinjiang Cai, Jaden Ji, Sydney Chen, Abigail Vera, Kristina I Boström, Yucheng Yao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yan ZhaoDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Yang YangDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Xiuju WuDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Li ZhangDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Xinjiang CaiDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Jaden JiDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Sydney ChenDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Abigail VeraDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Kristina I BoströmDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Yucheng YaoDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

Molecular Mechanisms of MGP; Role in AVMsR01HL081397 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2006 to 2025
$7.7M
BMP and Notch Crosstalk in Cerebral Arteriovenous MalformationsR01NS079353 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2012 to 2026
$5.3M
Switch of Osteogenesis in Vascular CalcificationR01HL139675 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2018 to 2026
$3.6M
Endothelial Regulation of Vascular CalcificationR01HL158053 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2022 to 2025
$2.2M
Erasing ill features of arterial endothelial cells in hereditary hemorrhagic telangiectasiaR01HL162643 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YAO, YUCHENG · 2022 to 2025
$1.6M
Regulation of Vascular Calcification by Adventitial Endothelial CellsK08HL168147 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xinjiang Cai · 2023 to 2026
$692k
NHLBI NIH HHS K08 HL168147NHLBI NIH HHS R01 HL081397NHLBI NIH HHS R01 HL139675NHLBI NIH HHS R01 HL158053NHLBI NIH HHS R01 HL162643NINDS NIH HHS R01 NS079353
6 · The paper itself

Abstract

Vascular calcification is a severe complication of cardiovascular diseases. Previous studies demonstrated that endothelial lineage cells transitioned into osteoblast-like cells and contributed to vascular calcification. Here, we found that inhibition of cyclin-dependent kinase (CDK) prevented endothelial lineage cells from transitioning to osteoblast-like cells and reduced vascular calcification. We identified a robust induction of CDK1 in endothelial cells (ECs) in calcified arteries and showed that EC-specific gene deletion of CDK1 decreased the calcification. We found that limiting CDK1 induced E-twenty-six specific sequence variant 2 (ETV2), which was responsible for blocking endothelial lineage cells from undergoing osteoblast differentiation. We also found that inhibition of CDK1 reduced vascular calcification in a diabetic mouse model. Together, the results highlight the importance of CDK1 suppression and suggest CDK1 inhibition as a potential option for treating vascular calcification.

Indexed as

OsteogenesisVascular CalcificationAnimalsCalcification, PhysiologicCDC2 Protein KinaseCell DifferentiationEndothelial CellsMiceCDC2 Protein KinaseCdk1 protein, mouseCardiovascular diseaseCell biologyVascular biology

Identifiers

PMID38456502
PMCPMC10972591
OpenAlexW4394760074

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.