Evidence map›Paper›PMID 38460121›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

BIN1

Laura Fernandez Garcia-Agudo, Zechuan Shi, Ian F Smith, Enikö A Kramár, Katelynn Tran, Shimako Kawauchi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi and 17 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Amyloid-Related Imaging Abnormality (ARIA) Beyond the APOE-ε4 Allele.Chronic diseases and translational medicine · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. BIN1Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 1 institution in 1 country.

Laura Fernandez Garcia-AgudoDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Zechuan ShiDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Ian F SmithDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Enikö A KramárDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Katelynn TranInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Shimako KawauchiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Shuling WangTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Sherilyn CollinsTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Amber WalkerTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Kai-Xuan ShiTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Jonathan NeumannTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Heidi Yahan LiangDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Celia Da CunhaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Giedre MilinkeviciuteInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Samuel MorabitoDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Emily MiyoshiDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Narges RezaieDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Angela Gomez-ArboledasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Adrian Mendoza ArvillaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Daryan Iman GhaemiDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Andrea J TennerDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Frank M LaFerlaDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Marcelo A WoodDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Ali MortazaviDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Vivek SwarupDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Grant R MacGregorTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Kim N GreenDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
University of California, Irvine · US

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9M
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
NCI NIH HHS P30 CA062203NCI NIH HHS P30CA062203NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

introductionThe BIN1 coding variant rs138047593 (K358R) is linked to Late-Onset Alzheimer's Disease (LOAD) via targeted exome sequencing.

methodsTo elucidate the functional consequences of this rare coding variant on brain amyloidosis and neuroinflammation, we generated BIN1

resultsThe presence of the BIN1 DISCUSSION: The BIN1 K358R variant modulates amyloid pathology in 5xFAD mice, attenuates the astrocytic and oligodendrocytic responses to amyloid plaques, decreases damage markers, and elevates synaptic densities. HIGHLIGHTS: BIN1 rs138047593 (K358R) coding variant is associated with increased risk of LOAD. BIN1 K358R variant increases amyloid plaque load in 12-month-old 5xFAD mice. BIN1 K358R variant dampens astrocytic and oligodendrocytic response to plaques. BIN1 K358R variant decreases neuronal damage in 5xFAD mice. BIN1 K358R upregulates synaptic densities and modulates synaptic transmission.

Indexed as

Alzheimer DiseaseAdaptor Proteins, Signal TransducingAmyloid beta-PeptidesAnimalsDisease Models, AnimalHumansMiceMice, TransgenicNeurogliaNuclear ProteinsPlaque, AmyloidTumor Suppressor ProteinsAdaptor Proteins, Signal TransducingAmyloid beta-PeptidesBIN1 protein, humanNuclear ProteinsTumor Suppressor ProteinsAlzheimer's diseaseastrocytesBIN1 K358RinflammationMODEL‐ADoligodendrocytes

Identifiers

PMID38460121
PMCPMC11032570
OpenAlexW4392623298

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.