Evidence map›Paper›PMID 38460131›Full record

ArticleCell reports2024

Development of activity-based anorexia requires PKC-δ neurons in two central extended amygdala nuclei.

Wesley Ilana Schnapp, JungMin Kim, Yong Wang, Sayujya Timilsena, Caohui Fang, Haijiang Cai

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. A Distinct Subpopulation of Extended Amygdala Neurons Drives Food Intake.Biological psychiatry global open science · 2026
    Article
  2. Neural circuits regulating activity-based anorexia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Central amygdalar PKCδ neurons mediate fentanyl withdrawal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Review
  5. A Distinct Subpopulation of Extended Amygdala Neurons Drives Food Intake.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Wesley Ilana SchnappDepartment of Neuroscience, University of Arizona, Tucson, AZ 85721, USA; Graduate Interdisciplinary Program in Neuroscience, University of Arizona, Tucson, AZ 85721, USA.
JungMin KimDepartment of Neuroscience, University of Arizona, Tucson, AZ 85721, USA.
Yong WangDepartment of Neuroscience, University of Arizona, Tucson, AZ 85721, USA; Department of Physiology and Pathophysiology, Xi'an Jiaotong University Health Science Center, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, PR China.
Sayujya TimilsenaDepartment of Neuroscience, University of Arizona, Tucson, AZ 85721, USA.
Caohui FangDepartment of Neuroscience, University of Arizona, Tucson, AZ 85721, USA.
Haijiang CaiDepartment of Neuroscience, University of Arizona, Tucson, AZ 85721, USA; Bio5 Institute and Department of Neurology, University of Arizona, Tucson, AZ 85721, USA. Electronic address: haijiangcai@arizona.edu.
University of Arizona · US

Funding

Dissecting a central amygdala-parasubthalamic nucleus circuitry underlying appetite controlR01DK124501 · NIDDK · UNIVERSITY OF ARIZONA · PI CAI, HAIJIANG · 2021 to 2025
$1.9M
NIDDK NIH HHS R01 DK124501
6 · The paper itself

Abstract

Anorexia nervosa (AN) is a serious psychiatric disease, but the neural mechanisms underlying its development are unclear. A subpopulation of amygdala neurons, marked by expression of protein kinase C-delta (PKC-δ), has previously been shown to regulate diverse anorexigenic signals. Here, we demonstrate that these neurons regulate development of activity-based anorexia (ABA), a common animal model for AN. PKC-δ neurons are located in two nuclei of the central extended amygdala (EAc): the central nucleus (CeA) and oval region of the bed nucleus of the stria terminalis (ovBNST). Simultaneous ablation of CeA

Indexed as

Central Amygdaloid NucleusSeptal NucleiAnimalsAnorexiaNeural PathwaysNeuronsProtein Kinase C-deltaProtein Kinase C-deltaactivity-based anorexiaanorexia nervosabed nucleus of stria terminalis (BNST)central amygdala (CeA)central extended amygdalaCP: Neuroscienceeating disorderenergy homeostasisneural circuitsprotein kinase C-delta

Identifiers

PMID38460131
PMCPMC11003439
OpenAlexW4392578241

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.