Evidence map›Paper›PMID 38461051›Full record

ReviewVaccine2024

Current vaccine strategies and novel approaches to combatting Francisella infection.

Jaikin E Harrell, Chad J Roy, John S Gunn, James B McLachlan

Open access · hybridAbstract readReview
In one paragraph

Review in Vaccine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. mBio · 2026
    Article
  3. Review
  4. Article
  5. The immune response toFrontiers in microbiology · 2025
    Review
  6. Identification of theFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jaikin E HarrellDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Chad J RoyDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
John S GunnCenter for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio, USA, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA.
James B McLachlanDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA. Electronic address: jmclachl@tulane.edu.
Tulane University · USThe Ohio State University · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Using parenteral combination adjuvants to induce pan-mucosal cellular and humoral immunityR01AI166756 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI MCLACHLAN, JAMES B, MORICI, LISA A · 2022 to 2025
$3.3M
NIAID NIH HHS R01 AI166756NIH HHS P51 OD011104
6 · The paper itself

Abstract

Tularemia is caused by subspecies of Francisella tularensis and can manifest in a variety of disease states, with the pneumonic presentation resulting in the greatest mortality. Despite decades of research, there are no approved vaccines against F. tularensis in the United States. Traditional vaccination strategies, such as live-attenuated or subunit vaccines, are not favorable due to inadequate protection or safety concerns. Because of this, novel vaccination strategies are needed to combat tularemia. Here we discuss the current state of and challenges to the tularemia vaccine field and suggest novel vaccine approaches going forward that might be better suited for protecting against F. tularensis infection.

Indexed as

Francisella tularensisTularemiaBacterial VaccinesHumansVaccinationVaccines, AttenuatedBacterial VaccinesVaccines, AttenuatedcorrelatesFrancisellananoparticleT celltularemiavaccine

Identifiers

PMID38461051
PMCPMC11095077
OpenAlexW4392599684

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.