ArticlebioRxiv : the preprint server for biology2024
Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4
Augustine Fert, Jonathan Richard, Laurence Raymond Marchand, Delphine Planas, Jean-Pierre Routy, Nicolas Chomont, Andrés Finzi, Petronela Ancuta
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors at 2 institutions in 1 country.
Augustine FertCentre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC, H2X 0A9, Canada.
Jonathan RichardCentre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC, H2X 0A9, Canada.
Laurence Raymond MarchandCentre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC, H2X 0A9, Canada.
Delphine PlanasCentre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC, H2X 0A9, Canada.
Jean-Pierre RoutyInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.
Nicolas ChomontCentre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC, H2X 0A9, Canada.ORCID 0000-0001-9747-5018 Andrés FinziCentre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC, H2X 0A9, Canada.
Petronela AncutaCentre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC, H2X 0A9, Canada.ORCID 0000-0003-1922-5640 Centre Hospitalier de l’Université de Montréal · CAMcGill University Health Centre · CA
Funding
Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$5.0MERASE HIV: Enterprise for Research and Advancements to Stop and Eradicate HIVUM1AI164562 · EMORY UNIVERSITY · 2025 to 2025
$4.7MExploring HIV-1 Env open conformations for therapeutic interventionR01AI150322 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2022 to 2025
$2.4MAssessing ADCC and Fc-mediated Protection against HIVR01AI148379 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI David T Evans, Andres Finzi · 2023 to 2023
$767kNIAID NIH HHS R01 AI148379NIAID NIH HHS R01 AI150322NIAID NIH HHS UM1 AI164560NIAID NIH HHS UM1 AI164562
6 · The paper itselfAbstract
The mechanistic target of rapamycin (mTOR) positively regulates multiple steps of the HIV-1 replication cycle. We previously reported that a 12-weeks supplementation of antiretroviral therapy (ART) with metformin, an indirect mTOR inhibitor used in type-2 diabetes treatment, reduced mTOR activation and HIV transcription in colon-infiltrating CD4
Identifiers
PMID38464135
PMCPMC10925111
OpenAlexW4391925565
What Socratic holds
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LicenceCC BY-NC-ND
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