Evidence map›Paper›PMID 38464138›Full record

ArticlebioRxiv : the preprint server for biology2024

Suppressing APOE4-induced mortality and cellular damage by targeting VHL.

Wei I Jiang, Yiming Cao, Yue Xue, Yichun Ji, Benjamin Y Winer, Mengqi Zhang, Neel S Singhal, Jonathan T Pierce, Song Chen, Dengke K Ma

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Wei I JiangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Yiming CaoJiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Yue XueJiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Yichun JiJiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Benjamin Y WinerCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Mengqi ZhangDepartment of Neurology, University of California, San Francisco, San Francisco, USA.
Neel S SinghalDepartment of Neurology, University of California, San Francisco, San Francisco, USA.ORCID 0000-0003-1605-4444
Jonathan T PierceDepartment of Neuroscience, The Center for Learning and Memory, Waggoner Center for Alcohol and Addiction Research, Institute of Neuroscience, University of Texas at Austin, Austin, Texas, USA.
Song ChenJiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Dengke K MaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5619-7485
China Pharmaceutical University · CNUniversity of California, San Francisco · USMemorial Sloan Kettering Cancer Center · USThe University of Texas at Austin · US

Funding

Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermiaR35GM139618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 to 2025
$1.5M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$455k
NIA NIH HHS RF1 AG057355NIGMS NIH HHS R35 GM139618NIH HHS P40 OD010440NIH HHS R21 OD032463
6 · The paper itself

Abstract

Mortality rate increases with age and can accelerate upon extrinsic or intrinsic damage to individuals. Identifying factors and mechanisms that curb population mortality rate has wide-ranging implications. Here, we show that targeting the VHL-1 (Von Hippel-Lindau) protein suppresses

Identifiers

PMID38464138
PMCPMC10925324
OpenAlexW4392342359

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.