Evidence map›Paper›PMID 38464315›Full record

ArticleResearch square2024

Circulating Tumor Reactive KIR+CD8+ T cells Suppress Anti-Tumor Immunity in Patients with Melanoma.

David Hafler, Benjamin Lu, Liliana Lucca, Wesley Lewis, Jiping Wang, Catarina Nogeuira, Sebastian Heer, Pierre-Paul Axisa, Nicholas Buitrago-Pocasangre, Giang Pham and 15 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 2 countries.

David HaflerYale University.ORCID 0000-0003-4664-535X
Benjamin LuYale School of Medicine.ORCID 0000-0001-8764-8384
Liliana LuccaYale School of Medicine.
Wesley LewisYale University.
Jiping WangYale School of Public Health.
Catarina NogeuiraRepertoire Immune Medicines.
Sebastian HeerRepertoire Immune Medicines.
Pierre-Paul AxisaYale University.ORCID 0000-0003-1446-3922
Nicholas Buitrago-PocasangreYale Medical School.ORCID 0000-0002-1333-4435
Giang PhamYale School of Medicine.
Mina KojimaDepartment of Genetics, Yale University.
Wei WeiYale School of Medicine.
Lilach AizenbudYale School of Medicine.
Antonietta BacchiocchiYale School of Medicine.
Lin ZhangYale School of Medicine.
Joseph WalewskiYale School of Medicine.
Veronica ChiangYale School of Medicine.
Kelly OlinoYale School of Medicine.
James CluneYale School of Medicine.
Ruth HalabanYale University School of Medicine.ORCID 0000-0001-8451-1964
Yuval KlugerYale University School of Medicine.ORCID 0000-0002-3035-071X
Anthony CoyleRepertoire Immune Medicines.
Jan KisielowRepertoire Immune Medicine (Switzerland).ORCID 0000-0002-4482-5202
Franz-Josef ObermairRepertoire Immune Medicine (Switzerland).ORCID 0000-0002-3918-800X
Harriet KlugerYale University School of Medicine.
Yale University · USAC Immune (Switzerland) · CH

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 1985 to 2026
$85.0M
Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI VIJAY K. KUCHROO · 1996 to 2026
$51.7M
Yale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI MARCUS W BOSENBERG, Harriet M. Kluger · 2006 to 2026
$43.9M
MEDICAL INFORMATICS RESEARCH TRAINING AT YALET15LM007056 · NLM · YALE UNIVERSITY · PI Mark Bender Gerstein, LUCILA OHNO-MACHADO · 1987 to 2026
$22.2M
A Catalog of Cell Types and Genomic Elements in Tissues, Organoids and DiseaseUM1HG009390 · NHGRI · BROAD INSTITUTE, INC. · PI BERNSTEIN, BRADLEY EVAN · 2017 to 2021
$11.0M
YALE CANCER CENTER CALABRESI IMMUNO-ONCOLOGY TRAINING PROGRAMK12CA215110 · NCI · YALE UNIVERSITY · PI Harriet M. Kluger · 2018 to 2026
$6.1M
(8) Mechanisms of autoimmune endocrine diseases in patients receiving checkpoint inhibitorsR01CA227473 · NCI · YALE UNIVERSITY · PI HEROLD, KEVAN C, KLUGER, HARRIET M. · 2018 to 2022
$3.2M
Yale Cancer Center Advanced Training Program for Physician-Scientists (YCC-ATPP)T32CA233414 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 2019 to 2026
$3.2M
Immune Therapy for Brain MetastasisR01CA269286 · NCI · YALE UNIVERSITY · PI Lucia Beatrice Jilaveanu, Harriet M. Kluger · 2023 to 2026
$2.2M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
NCI NIH HHS K12 CA215110NCI NIH HHS P30 CA016359NCI NIH HHS P50 CA121974NCI NIH HHS R01 CA227473NCI NIH HHS R01 CA269286NCI NIH HHS T32 CA233414NHGRI NIH HHS UM1 HG009390NIAID NIH HHS P01 AI039671NIH HHS S10 OD030363NLM NIH HHS T15 LM007056
6 · The paper itself

Abstract

Effective anti-tumor immunity is largely driven by cytotoxic CD8

Identifiers

PMID38464315
PMCPMC10925449
OpenAlexW4392229877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.