Evidence map›Paper›PMID 38465473›Full record

ArticleAging cell2024

Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan.

Gillian Borland, Stephen E Wilkie, Jackie Thomson, Zhe Wang, Jennifer M A Tullet, Nazif Alic, Colin Selman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gillian BorlandSchool of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Stephen E WilkieSchool of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Jackie ThomsonSchool of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Zhe WangSchool of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Jennifer M A TulletFaculty of Natural Sciences, University of Kent, Canterbury, UK.ORCID 0000-0002-2037-526X
Nazif AlicDepartment of Genetics Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.
Colin SelmanSchool of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.ORCID 0000-0002-8727-0593

Funding

Biotechnology and Biological Sciences Research Council BB/S014357/1Medical Research Council MR/N013166/1
6 · The paper itself

Abstract

The genetic pathways that modulate ageing in multicellular organisms are typically highly conserved across wide evolutionary distances. Recently RNA polymerase III (Pol III) was shown to promote ageing in yeast, C. elegans and D. melanogaster. In this study we investigated the role of Pol III in mammalian ageing using C57BL/6N mice heterozygous for Pol III (Polr3b

Indexed as

AgingHeterozygoteLongevityRNA Polymerase IIIAnimalsFemaleMaleMiceMice, Inbred C57BLRNA Polymerase IIIAgingC57BL/6NhealthspanlongevityRNA polymerase III

Identifiers

PMID38465473
PMCPMC11113255

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.